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Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context.

dc.contributor.author Arbeev, Konstantin
dc.contributor.author Culminskaya, IV
dc.contributor.author Kulminski, Alexander
dc.contributor.author Land, Kenneth C
dc.contributor.author Ukraintseva, Svetlana
dc.contributor.author Yashin, Anatoli I
dc.coverage.spatial Ireland
dc.date.accessioned 2017-06-07T19:39:20Z
dc.date.available 2017-06-07T19:39:20Z
dc.date.issued 2010-05
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/20399803
dc.identifier S0047-6374(10)00072-2
dc.identifier.uri https://hdl.handle.net/10161/14883
dc.description.abstract The Gln(27)Glu polymorphism but not the Arg(16)Gly polymorphism of the beta2-adrenergic receptor (ADRB2) gene appears to be associated with a broad range of aging-associated phenotypes, including cancers at different sites, myocardial infarction (MI), intermittent claudication (IC), and overall/healthy longevity in the Framingham Heart Study Offspring cohort. The Gln(27)Gln genotype increases risks of cancer, MI and IC, whereas the Glu(27) allele or, equivalently, the Gly(16)Glu(27) haplotype tends to be protective against these diseases. Genetic associations with longevity are of opposite nature at young-old and oldest-old ages highlighting the phenomenon of antagonistic pleiotropy. The mechanism of antagonistic pleiotropy is associated with an evolutionary-driven advantage of carriers of a derived Gln(27) allele at younger ages and their survival disadvantage at older ages as a result of increased risks of cancer, MI and IC. The ADRB2 gene can play an important systemic role in healthy aging in evolutionary context that warrants exploration in other populations.
dc.language eng
dc.relation.ispartof Mech Ageing Dev
dc.relation.isversionof 10.1016/j.mad.2010.04.001
dc.subject Adolescent
dc.subject Adult
dc.subject Aged
dc.subject Aging
dc.subject Alleles
dc.subject Amino Acid Substitution
dc.subject Cardiovascular Diseases
dc.subject Child
dc.subject Child, Preschool
dc.subject Evolution, Molecular
dc.subject Female
dc.subject Health
dc.subject Humans
dc.subject Longevity
dc.subject Male
dc.subject Middle Aged
dc.subject Polymorphism, Genetic
dc.subject Receptors, Adrenergic, beta-2
dc.subject Risk
dc.subject Young Adult
dc.title Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/20399803
pubs.begin-page 338
pubs.end-page 345
pubs.issue 5
pubs.organisational-group Center for Population Health & Aging
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Population Research Center
pubs.organisational-group Duke Population Research Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Sanford School of Public Policy
pubs.organisational-group School of Medicine
pubs.organisational-group Social Science Research Institute
pubs.organisational-group Sociology
pubs.organisational-group Staff
pubs.organisational-group Trinity College of Arts & Sciences
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 131
dc.identifier.eissn 1872-6216


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