Health and function of participants in the Long Life Family Study: A comparison with other cohorts.
Abstract
Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559)
were examined and compared to individuals from other cohorts to determine whether
the recruitment targeting longevity resulted in a cohort of individuals with better
health and function. Other cohorts with similar data included the Cardiovascular Health
Study, the Framingham Heart Study, and the New England Centenarian Study. Diabetes,
chronic pulmonary disease and peripheral artery disease tended to be less common in
LLFS probands and offspring compared to similar aged persons in the other cohorts.
Pulse pressure and triglycerides were lower, high density lipids were higher, and
a perceptual speed task and gait speed were better in LLFS. Age-specific comparisons
showed differences that would be consistent with a higher peak, later onset of decline
or slower rate of change across age in LLFS participants. These findings suggest several
priority phenotypes for inclusion in future genetic analysis to identify loci contributing
to exceptional survival.
Type
Journal articleSubject
AgedAged, 80 and over
Aging
Blood Pressure
Cardiovascular Diseases
Cohort Studies
Female
Gait
Humans
Longevity
Male
Middle Aged
Psychomotor Performance
Research Design
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https://hdl.handle.net/10161/14915Published Version (Please cite this version)
10.18632/aging.100242Publication Info
Newman, Anne B; Glynn, Nancy W; Taylor, Christopher A; Sebastiani, Paola; Perls, Thomas
T; Mayeux, Richard; ... Hadley, Evan (2011). Health and function of participants in the Long Life Family Study: A comparison with
other cohorts. Aging (Albany NY), 3(1). pp. 63-76. 10.18632/aging.100242. Retrieved from https://hdl.handle.net/10161/14915.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Anatoli I. Yashin
Research Professor in the Social Science Research Institute

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