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Health and function of participants in the Long Life Family Study: A comparison with other cohorts.

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Date
2011-01
Authors
Newman, Anne B
Glynn, Nancy W
Taylor, Christopher A
Sebastiani, Paola
Perls, Thomas T
Mayeux, Richard
Christensen, Kaare
Zmuda, Joseph M
Barral, Sandra
Lee, Joseph H
Simonsick, Eleanor M
Walston, Jeremy D
Yashin, Anatoli I
Hadley, Evan
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(14 total)
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Abstract
Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559) were examined and compared to individuals from other cohorts to determine whether the recruitment targeting longevity resulted in a cohort of individuals with better health and function. Other cohorts with similar data included the Cardiovascular Health Study, the Framingham Heart Study, and the New England Centenarian Study. Diabetes, chronic pulmonary disease and peripheral artery disease tended to be less common in LLFS probands and offspring compared to similar aged persons in the other cohorts. Pulse pressure and triglycerides were lower, high density lipids were higher, and a perceptual speed task and gait speed were better in LLFS. Age-specific comparisons showed differences that would be consistent with a higher peak, later onset of decline or slower rate of change across age in LLFS participants. These findings suggest several priority phenotypes for inclusion in future genetic analysis to identify loci contributing to exceptional survival.
Type
Journal article
Subject
Aged
Aged, 80 and over
Aging
Blood Pressure
Cardiovascular Diseases
Cohort Studies
Female
Gait
Humans
Longevity
Male
Middle Aged
Psychomotor Performance
Research Design
Permalink
https://hdl.handle.net/10161/14915
Published Version (Please cite this version)
10.18632/aging.100242
Publication Info
Newman, Anne B; Glynn, Nancy W; Taylor, Christopher A; Sebastiani, Paola; Perls, Thomas T; Mayeux, Richard; ... Hadley, Evan (2011). Health and function of participants in the Long Life Family Study: A comparison with other cohorts. Aging (Albany NY), 3(1). pp. 63-76. 10.18632/aging.100242. Retrieved from https://hdl.handle.net/10161/14915.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Yashin

Anatoli I. Yashin

Research Professor in the Social Science Research Institute
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