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Health and function of participants in the Long Life Family Study: A comparison with other cohorts.

dc.contributor.author Barral, S
dc.contributor.author Christensen, Kaare
dc.contributor.author Glynn, NW
dc.contributor.author Hadley, E
dc.contributor.author Lee, JH
dc.contributor.author Mayeux, R
dc.contributor.author Newman, Anne B
dc.contributor.author Perls, TT
dc.contributor.author Sebastiani, P
dc.contributor.author Simonsick, EM
dc.contributor.author Taylor, CA
dc.contributor.author Walston, JD
dc.contributor.author Yashin, Anatoli I
dc.contributor.author Zmuda, JM
dc.coverage.spatial United States
dc.date.accessioned 2017-06-09T19:47:21Z
dc.date.available 2017-06-09T19:47:21Z
dc.date.issued 2011-01
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/21258136
dc.identifier 100242
dc.identifier.uri http://hdl.handle.net/10161/14915
dc.description.abstract Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559) were examined and compared to individuals from other cohorts to determine whether the recruitment targeting longevity resulted in a cohort of individuals with better health and function. Other cohorts with similar data included the Cardiovascular Health Study, the Framingham Heart Study, and the New England Centenarian Study. Diabetes, chronic pulmonary disease and peripheral artery disease tended to be less common in LLFS probands and offspring compared to similar aged persons in the other cohorts. Pulse pressure and triglycerides were lower, high density lipids were higher, and a perceptual speed task and gait speed were better in LLFS. Age-specific comparisons showed differences that would be consistent with a higher peak, later onset of decline or slower rate of change across age in LLFS participants. These findings suggest several priority phenotypes for inclusion in future genetic analysis to identify loci contributing to exceptional survival.
dc.language eng
dc.relation.ispartof Aging (Albany NY)
dc.relation.isversionof 10.18632/aging.100242
dc.subject Aged
dc.subject Aged, 80 and over
dc.subject Aging
dc.subject Blood Pressure
dc.subject Cardiovascular Diseases
dc.subject Cohort Studies
dc.subject Female
dc.subject Gait
dc.subject Humans
dc.subject Longevity
dc.subject Male
dc.subject Middle Aged
dc.subject Psychomotor Performance
dc.subject Research Design
dc.title Health and function of participants in the Long Life Family Study: A comparison with other cohorts.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/21258136
pubs.begin-page 63
pubs.end-page 76
pubs.issue 1
pubs.organisational-group Center for Population Health & Aging
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Population Research Center
pubs.organisational-group Duke Population Research Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Sanford School of Public Policy
pubs.organisational-group School of Medicine
pubs.organisational-group Social Science Research Institute
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 3
dc.identifier.eissn 1945-4589


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