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RNA-Based Vaccines in Cancer Immunotherapy.

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Date
2015
Authors
McNamara, Megan A
Nair, Smita K
Holl, Eda K
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Abstract
RNA vaccines traditionally consist of messenger RNA synthesized by in vitro transcription using a bacteriophage RNA polymerase and template DNA that encodes the antigen(s) of interest. Once administered and internalized by host cells, the mRNA transcripts are translated directly in the cytoplasm and then the resulting antigens are presented to antigen presenting cells to stimulate an immune response. Alternatively, dendritic cells can be loaded with either tumor associated antigen mRNA or total tumor RNA and delivered to the host to elicit a specific immune response. In this review, we will explain why RNA vaccines represent an attractive platform for cancer immunotherapy, discuss modifications to RNA structure that have been developed to optimize mRNA vaccine stability and translational efficiency, and describe strategies for nonviral delivery of mRNA vaccines, highlighting key preclinical and clinical data related to cancer immunotherapy.
Type
Journal article
Subject
Animals
Antigen Presentation
Antigens, Neoplasm
Cancer Vaccines
Clinical Trials as Topic
Cytotoxicity, Immunologic
Dendritic Cells
Disease Models, Animal
Humans
Lymphocyte Activation
Neoplasms
RNA, Messenger
Permalink
https://hdl.handle.net/10161/14926
Published Version (Please cite this version)
10.1155/2015/794528
Publication Info
McNamara, Megan A; Nair, Smita K; & Holl, Eda K (2015). RNA-Based Vaccines in Cancer Immunotherapy. J Immunol Res, 2015. pp. 794528. 10.1155/2015/794528. Retrieved from https://hdl.handle.net/10161/14926.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Holl

Eda K Holl

Adjunct Assistant Professor in the Department of Surgery
Nair

Smita K Nair

Professor in Surgery
I have 22 years of experience in the field of cancer vaccines and immunotherapy and I am an accomplished T cell immunologist. Laboratory website:https://surgery.duke.edu/immunology-inflammation-immunotherapy-laboratory Current projects in the Nair Laboratory:1] Dendritic cell vaccines using tumor-antigen encoding RNA (mRNA, total tumor RNA, amplified tumor mRNA)<br
Alphabetical list of authors with Scholars@Duke profiles.
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