RNA-Based Vaccines in Cancer Immunotherapy.
Abstract
RNA vaccines traditionally consist of messenger RNA synthesized by in vitro transcription
using a bacteriophage RNA polymerase and template DNA that encodes the antigen(s)
of interest. Once administered and internalized by host cells, the mRNA transcripts
are translated directly in the cytoplasm and then the resulting antigens are presented
to antigen presenting cells to stimulate an immune response. Alternatively, dendritic
cells can be loaded with either tumor associated antigen mRNA or total tumor RNA and
delivered to the host to elicit a specific immune response. In this review, we will
explain why RNA vaccines represent an attractive platform for cancer immunotherapy,
discuss modifications to RNA structure that have been developed to optimize mRNA vaccine
stability and translational efficiency, and describe strategies for nonviral delivery
of mRNA vaccines, highlighting key preclinical and clinical data related to cancer
immunotherapy.
Type
Journal articleSubject
AnimalsAntigen Presentation
Antigens, Neoplasm
Cancer Vaccines
Clinical Trials as Topic
Cytotoxicity, Immunologic
Dendritic Cells
Disease Models, Animal
Humans
Lymphocyte Activation
Neoplasms
RNA, Messenger
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https://hdl.handle.net/10161/14926Published Version (Please cite this version)
10.1155/2015/794528Publication Info
McNamara, Megan A; Nair, Smita K; & Holl, Eda K (2015). RNA-Based Vaccines in Cancer Immunotherapy. J Immunol Res, 2015. pp. 794528. 10.1155/2015/794528. Retrieved from https://hdl.handle.net/10161/14926.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Eda K Holl
Adjunct Assistant Professor in the Department of Surgery
Smita K Nair
Professor in Surgery
I have 22 years of experience in the field of cancer vaccines and immunotherapy and
I am an accomplished T cell immunologist. Laboratory website:https://surgery.duke.edu/immunology-inflammation-immunotherapy-laboratory
Current projects in the Nair Laboratory:1] Dendritic cell vaccines using tumor-antigen
encoding RNA (mRNA, total tumor RNA, amplified tumor mRNA)<br
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