Show simple item record

Outcomes Associated With Familial Versus Nonfamilial Atrial Fibrillation: A Matched Nationwide Cohort Study.

dc.contributor.author Gundlund, Anna
dc.contributor.author Olesen, Jonas Bjerring
dc.contributor.author Staerk, Laila
dc.contributor.author Lee, Christina
dc.contributor.author Piccini, Jonathan P
dc.contributor.author Peterson, Eric D
dc.contributor.author Køber, Lars
dc.contributor.author Torp-Pedersen, Christian
dc.contributor.author Gislason, Gunnar H
dc.contributor.author Fosbøl, Emil Loldrup
dc.coverage.spatial England
dc.date.accessioned 2017-07-06T13:25:57Z
dc.date.available 2017-07-06T13:25:57Z
dc.date.issued 2016-11-19
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/27866162
dc.identifier JAHA.116.003836
dc.identifier.uri https://hdl.handle.net/10161/14991
dc.description.abstract BACKGROUND: We examined all-cause mortality and long-term thromboembolic risk (ischemic stroke, transient ischemic attack, systemic thromboembolism) in patients with and without familial atrial fibrillation (AF). METHODS AND RESULTS: Using Danish nationwide registry data, we identified all patients diagnosed with AF (1995-2012) and divided them into those with familial AF (having a first-degree family member with a prior AF admission) and those with nonfamilial AF. We paired those with and without familial AF according to age, year of AF diagnosis, and sex in a 1:1 match. Using cumulative incidence and multivariable Cox models, we examined the risk of long-term outcomes. We identified 8658 AF patients (4329 matched pairs) with and without familial AF. The median age was 50 years (interquartile range 43-54 years), and 21.4% were women. Compared with nonfamilial AF patients, those with familial AF had slightly less comorbid illness but similar overall CHA2DS2-VASc score (P=0.155). Median follow-up was 3.4 years (interquartile range 1.5-6.5 years). Patients with familial AF had risk of death and thromboembolism similar to those with nonfamilial AF (adjusted hazard ratio 0.91 [95% CI 0.79-1.04] for death and 0.90 [95% CI 0.71-1.14] for thromboembolism). CONCLUSIONS: Although family history of AF is associated with increased likelihood for development of AF, once AF developed, long-term risks of death and thromboembolic complications were similar in familial and nonfamilial AF patients.
dc.language eng
dc.publisher Ovid Technologies (Wolters Kluwer Health)
dc.relation.ispartof J Am Heart Assoc
dc.relation.isversionof 10.1161/JAHA.116.003836
dc.subject atrial flutter
dc.subject complication
dc.subject family history
dc.subject genetics
dc.title Outcomes Associated With Familial Versus Nonfamilial Atrial Fibrillation: A Matched Nationwide Cohort Study.
dc.type Journal article
duke.contributor.id Piccini, Jonathan P|0373399
duke.contributor.id Peterson, Eric D|0130909
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/27866162
pubs.issue 11
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Clinical Research Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Cardiology
pubs.organisational-group School of Medicine
pubs.publication-status Published online
pubs.volume 5
dc.identifier.eissn 2047-9980
duke.contributor.orcid Peterson, Eric D|0000-0002-5415-4721


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record