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The design of an observational study of hypertension management, adherence and pressure control in Blood Pressure Success Zone Program participants.

dc.contributor.author BPSZ-BLISS Study Steering Committee
dc.contributor.author Califf, Robert M
dc.contributor.author Caro, JJ
dc.contributor.author Daley, WL
dc.contributor.author Flack, J
dc.contributor.author Ishak, KJ
dc.contributor.author Khan, ZM
dc.contributor.author Morisky, D
dc.contributor.author Nesbitt, S
dc.contributor.author Payne, KA
dc.contributor.author Purkayastha, D
dc.contributor.author Stark, K
dc.contributor.author Velazquez, Eric J
dc.coverage.spatial England
dc.date.accessioned 2017-07-07T14:00:21Z
dc.date.available 2017-07-07T14:00:21Z
dc.date.issued 2008-09
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/18647193
dc.identifier IJCP1840
dc.identifier.uri http://hdl.handle.net/10161/15030
dc.description.abstract AIMS: The Blood Pressure Success Zone (BPSZ) Program, a nationwide initiative, provides education in addition to a complimentary trial of one of three antihypertensive medications. The BPSZ Longitudinal Observational Study of Success (BPSZ-BLISS) aims to evaluate blood pressure (BP) control, adherence, persistence and patient satisfaction in a representative subset of BPSZ Program participants. The BPSZ-BLISS study design is described here. METHODS: A total of 20,000 physicians were invited to participate in the study. Using a call centre supported Interactive Voice Response System (IVRS), physicians report BP and other data at enrolment and every usual care visit up to 12 +/- 2 months; subjects self-report BPs, persistence, adherence and treatment satisfaction at 3, 6 and 12 months post-BPSZ Program enrolment. In addition to BPSZ Program enrolment medications, physicians prescribe antihypertensive medications and schedule visits as per usual care. The General Electric Healthcare database will be used as an external reference. RESULTS: After 18 months, over 700 IRB approved physicians consented and enrolled 10,067 eligible subjects (48% male; mean age 56 years; 27% newly diagnosed); 97% of physicians and 78% of subjects successfully entered IVRS enrolment data. Automated IVRS validations have maintained data quality (< 5% error on key variables). Enrolment was closed 30 April 2007; study completion is scheduled for June 2008. CONCLUSIONS: The evaluation of large-scale health education programmes requires innovative methodologies and data management and quality control processes. The BPSZ-BLISS design can provide insights into the conceptualisation and planning of similar studies.
dc.language eng
dc.relation.ispartof Int J Clin Pract
dc.relation.isversionof 10.1111/j.1742-1241.2008.01840.x
dc.subject Adolescent
dc.subject Adult
dc.subject Aged
dc.subject Antihypertensive Agents
dc.subject Clinical Trials as Topic
dc.subject Female
dc.subject Humans
dc.subject Hypertension
dc.subject Male
dc.subject Middle Aged
dc.subject Patient Compliance
dc.subject Patient Education as Topic
dc.subject Patient Satisfaction
dc.subject Research Design
dc.subject Treatment Outcome
dc.subject Young Adult
dc.title The design of an observational study of hypertension management, adherence and pressure control in Blood Pressure Success Zone Program participants.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/18647193
pubs.begin-page 1313
pubs.end-page 1321
pubs.issue 9
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Clinical Research Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Cardiology
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 62
dc.identifier.eissn 1742-1241


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