Hürthle cell carcinoma: current perspectives.
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Hürthle cell carcinoma (HCC) can present either as a minimally invasive or as a widely invasive tumor. HCC generally has a more aggressive clinical behavior compared with the other differentiated thyroid cancers, and it is associated with a higher rate of distant metastases. Minimally invasive HCC demonstrates much less aggressive behavior; lesions <4 cm can be treated with thyroid lobectomy alone, and without radioactive iodine (RAI). HCC has been observed to be less iodine-avid compared with other differentiated thyroid cancers; however, recent data have demonstrated improved survival with RAI use in patients with HCC >2 cm and those with nodal and distant metastases. Patients with localized iodine-resistant disease who are not candidates for a wait-and-watch approach can be treated with localized therapies. Systemic therapy is reserved for patients with progressive, widely metastatic HCC.
SubjectHurthle cell lesion
follicular cell carcinoma
minimally invasive HCC
Published Version (Please cite this version)10.2147/OTT.S119980
Publication InfoAhmadi, Sara; Stang, Michael Tracey; Jiang, XS; & Sosa, Julie Ann (2016). Hürthle cell carcinoma: current perspectives. Onco Targets Ther, 9. pp. 6873-6884. 10.2147/OTT.S119980. Retrieved from http://hdl.handle.net/10161/15141.
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Assistant Professor of Medicine
Professor of Surgery
Julie Ann Sosa, MD MA FACS is Chief of Endocrine Surgery at Duke University and leader of the endocrine neoplasia diseases group in the Duke Cancer Institute and the Duke Clinical Research Institute. She is Professor of Surgery and Medicine. Her clinical interest is in endocrine surgery, with a focus in thyroid cancer. She is widely published in outcomes analysis, as well as cost-effectiveness analysis, meta-analysis, and survey-based research, and she is director of health services research for
Associate Professor of Surgery
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