Cerebral oxygenation and optimal vascular brain organization.
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The cerebral vascular network has evolved in such a way so as to minimize transport time and energy expenditure. This is accomplished by a subtle combination of the optimal arrangement of arteries, arterioles and capillaries and the transport mechanisms of convection and diffusion. Elucidating the interaction between cerebral vascular architectonics and the latter physical mechanisms can catalyse progress in treating cerebral pathologies such as stroke, brain tumours, dementia and targeted drug delivery. Here, we show that brain microvascular organization is predicated on commensurate intracapillary oxygen convection and parenchymal diffusion times. Cross-species grey matter results for the rat, cat, rabbit and human reveal very good correlation between the cerebral capillary and tissue mean axial oxygen convective and diffusion time intervals. These findings agree with the constructal principle.
Subjectdiffusion and convection time
mammalian vascular architecture
Published Version (Please cite this version)10.1098/rsif.2015.0245
Publication InfoHadjistassou, Constantinos; Bejan, Adrian; & Ventikos, Yiannis (2015). Cerebral oxygenation and optimal vascular brain organization. J R Soc Interface, 12(107). 10.1098/rsif.2015.0245. Retrieved from https://hdl.handle.net/10161/15208.
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J.A. Jones Distinguished Professor of Mechanical Engineering
Professor Bejan's research covers engineering science and applied physics: thermodynamics, heat transfer, convection, design, and evolution in nature. Professor Bejan was ranked in 2001 among the 100 most highly cited authors worldwide in engineering (all fields, all countries), the Institute for Scientific Information. Professor Bejan has received 18 honorary doctorates from universities in 11 countries. Adrian Bejan is the author of 30 books and over 650 peer-referred