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Interactions between social/ behavioral factors and ADRB2 genotypes may be associated with health at advanced ages in China.

dc.contributor.author Zeng, Yi
dc.contributor.author Cheng, L
dc.contributor.author Zhao, L
dc.contributor.author Tan, Q
dc.contributor.author Feng, Q
dc.contributor.author Chen, H
dc.contributor.author Shen, K
dc.contributor.author Li, J
dc.contributor.author Zhang, F
dc.contributor.author Cao, H
dc.contributor.author Gregory, Simon Gray
dc.contributor.author Yang, Z
dc.contributor.author Gu, J
dc.contributor.author Tao, W
dc.contributor.author Tian, X-L
dc.contributor.author Hauser, Elizabeth Rebecca
dc.coverage.spatial England
dc.date.accessioned 2017-08-28T15:53:03Z
dc.date.available 2017-08-28T15:53:03Z
dc.date.issued 2013-09-09
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/24016068
dc.identifier 1471-2318-13-91
dc.identifier.uri http://hdl.handle.net/10161/15374
dc.description.abstract BACKGROUND: Existing literature indicates that ADRB2 gene is associated with health and longevity, but none of previous studies investigated associations of carrying the ADRB2 minor alleles and interactions between ADRB2 genotypes and social/behavioral factors(GxE) with health outcomes at advanced ages. This study intends to fill in this research gap. METHOD: We conducted an exploratory analysis, using longitudinal survey phenotype/genotype data from 877 oldest-old aged 90+. To estimate association of GxE interactions with health outcome, adjusted for the potential correlation between genotypes and social/behavioral factors and various other potentially confounding factors, we develop and test an innovative three-step procedure which combines logistic regression and structural equation methods. RESULTS: Interaction between regular exercise and carrying rs1042718 minor allele is significantly and positively associated with good cognitive function; interaction between regular exercise and carrying rs1042718 or rs1042719 minor allele is significantly and positively associated with self-reported good health; and interaction between social-leisure activities and carrying rs1042719 minor allele is significantly and positively associated with self-reported good health. Carrying rs1042718 or rs1042719 minor alleles is significantly and negatively associated with negative emotion, but the ADRB2 SNPs are not significantly associated with cognitive function and self-reported health. Our structural equation analysis found that, adjusted for the confounding effects of correlation of the ADRB2 SNPs with negative emotion, interaction between negative emotion and carrying rs1042718 or rs1042719 minor allele is significantly and negatively associated with cognitive function. The positive association of regular exercise and social-leisure activities with cognitive function and self-reported health, and negative association of negative emotion with cognitive function, were much stronger among carriers of rs1042718 or rs1042719 alleles, compared to the non-carriers. CONCLUSIONS: The results indicate significant positive associations of interactions between social/behavioral factors and the ADRB2 genotypes with health outcomes of cognitive function and self-reported health, and negative associations of carrying rs1042718 or rs1042719 minor alleles with negative emotion, at advanced ages in China. Our findings are exploratory rather than causal conclusions. This study implies that near-future health promotion programs considering individuals' genetic profiles, with appropriate protection of privacy/confidentiality, would yield increased benefits and reduced costs to the programs and their participants.
dc.language eng
dc.relation.ispartof BMC Geriatr
dc.relation.isversionof 10.1186/1471-2318-13-91
dc.subject Aged, 80 and over
dc.subject Aging
dc.subject Asian Continental Ancestry Group
dc.subject China
dc.subject Female
dc.subject Genotype
dc.subject Health Status
dc.subject Health Surveys
dc.subject Humans
dc.subject Longitudinal Studies
dc.subject Male
dc.subject Receptors, Adrenergic, beta-2
dc.subject Social Behavior
dc.title Interactions between social/ behavioral factors and ADRB2 genotypes may be associated with health at advanced ages in China.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/24016068
pubs.begin-page 91
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biostatistics & Bioinformatics
pubs.organisational-group Center for Population Health & Aging
pubs.organisational-group Center for the Study of Aging and Human Development
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Molecular Physiology Institute
pubs.organisational-group Duke Population Research Center
pubs.organisational-group Duke Population Research Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Geriatrics
pubs.organisational-group Molecular Genetics and Microbiology
pubs.organisational-group Neurology
pubs.organisational-group Neurology, MS & Neuroimmunology
pubs.organisational-group Sanford School of Public Policy
pubs.organisational-group School of Medicine
pubs.publication-status Published online
pubs.volume 13
dc.identifier.eissn 1471-2318


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