Noninvasive measurement of tissue blood oxygenation with Cerenkov imaging during therapeutic radiation delivery
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© 2017 Optical Society of America. Tumor tissue oxygenation significantly affects the outcome of radiotherapy. Real-time monitoring of tumor hypoxia is highly desirable for effective radiotherapy, and is the basis for improved treatment because hypoxic tumor cells are more resistant to radiation damage than fully oxygenated cells. We propose to use Cerenkov imaging to monitor tumor hypoxia by means of tissue blood oxygenation without the need for any exogenous contrast agent. Using a rodent hypoxia model, we demonstrate that Cerenkov imaging can be used as a noninvasive and noncontact method to measure tissue blood oxygenation level during radiation delivery. The data from Cerenkov imaging were validated using near infrared spectrometry methods. The results demonstrate the feasibility of using Cerenkov imaging to monitor tumor hypoxia during therapeutic radiation delivery.
Published Version (Please cite this version)10.1364/OL.42.003101
Publication InfoDas, S; Dewhirst, Mark Wesley; Lam, SK; Oldham, Mark; Palmer, Gregory M; & Zhang, X (2017). Noninvasive measurement of tissue blood oxygenation with Cerenkov imaging during therapeutic radiation delivery. Optics Letters, 42(16). pp. 3101-3104. 10.1364/OL.42.003101. Retrieved from http://hdl.handle.net/10161/15411.
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Gustavo S. Montana Professor of Radiation Oncology, in the School of Medicine
Mark W. Dewhirst, DVM, PhD is the Gustavo S. Montana Professor of Radiation Oncology and Vice Director for Basic Science in the Duke Cancer Institute. Dr. Dewhirst has research interests in tumor hypoxia, angiogenesis, hyperthermia and drug transport. He has spent 30 years studying causes of tumor hypoxia and the use of hyperthermia to treat cancer. In collaboration with Professor David Needham in the Pratt School of Engineering, he has developed a novel thermally sensitive drug carrying liposom
Professor of Radiation Oncology
Dr Oldham is Professor in the Department of Radiation Oncology (primary) and Biomedical Engineering (Secondary). He is the Director of the Optical Biophysics and 3D Dosimetry Lab. The lab has received NIH R01 funding to develop optical imaging techniques for 3D dosimetry. We are also developing a new optical imaging technique for high-resolution 3D imaging of vascular networks and gene expression in unsectioned tissue samples. A range of applications are being explored through collaborations wit
Associate Professor of Radiation Oncology
Greg Palmer obtained his B.S. in Biomedical Engineering from Marquette University in 2000, after which he obtained his Ph.D. in BME from the University of Wisconsin, Madison. He is currently an Associate Professor in the Department of Radiation Oncology, Cancer Biology Division at Duke University Medical Center. His primary research focus has been identifying and exploiting the changes in absorption, scattering, and fluorescence properties of tissue associated with cancer progression and therape
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