Blood Pressure-Lowering Mechanisms of the DASH Dietary Pattern.
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Potential blood pressure- (BP-) lowering mechanisms of the DASH dietary pattern were measured in 20 unmedicated hypertensive adults in a controlled feeding study. At screening, participants averaged 44.3 ± 7.8 years, BMI 33.9 ± 6.6 Kg/m(2), and BP 144.2 ± 9.38/88.5 ± 6.03 mmHg. All consumed a control diet for one week, then were randomized to control or DASH for another two weeks (week one and two). With DASH, but not controls, SBP fell by 10.65 ± 12.89 (P = 0.023) and 9.60 ± 11.23 (P = 0.039) mmHg and DBP by 5.95 ± 8.01 (P = 0.069) and 8.60 ± 9.13 mmHg (P = 0.011) at the end of week one and two, respectively. Univariate regressions showed that changes in urinary sodium/potassium ratio (β = 1.99) and plasma renin activity (β = -15.78) and percent change in plasma nitrite after hyperemia were associated with SBP changes at week one (all P < 0.05). Plasma nitrite following hyperemia showed a treatment effect (P = 0.014) and increased at week two (P = 0.001). Pulse wave velocity decreased over time with DASH (trend P = 0.019), and reached significance at week two (P = 0.026). This response may be mediated by an improvement in upregulation of nitric oxide bioavailability. Early natriuresis and reductions in oxidative stress cannot be ruled out. Future studies are needed to verify these findings, assess the possibility of earlier effects, and examine other potential mediators.
Published Version (Please cite this version)10.1155/2012/472396
Publication InfoLin, Pao-Hwa; Allen, Jason D; Li, Yi-Ju; Yu, Miao; Lien, Lillian F; & Svetkey, Laura P (2012). Blood Pressure-Lowering Mechanisms of the DASH Dietary Pattern. J Nutr Metab, 2012. pp. 472396. 10.1155/2012/472396. Retrieved from https://hdl.handle.net/10161/15530.
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Adjunct Associate Professor in the Department of Community and Family Medicine
My research is focused on investigating vascular physiology and oxygen radical biochemistry in health and disease. This combination allows examination of changes in vascular signaling mechanisms at a basic level to be translated to physiological responses. I direct the Frederick R. Cobb Non-Invasive Vascular Research Laboratory at the Center for Living Campus and have Biochemistry space in GSRB1. My group is involved in collaborations with several other research groups and the
This author no longer has a Scholars@Duke profile, so the information shown here reflects their Duke status at the time this item was deposited.
Professor of Biostatistics and Bioinformatics
My research interest is in statistical genetics, primarily in statistical method development and its application for genetic research of human complex diseases. Here is the list of research topics: Statistical genetics: I have involved in the development of several family-based association methods for quantitative traits with or without censoring, and for detecting X-linked genes. With the availability of next generation sequencing data, we have ongoing projects to develop
Associate Professor in Medicine
My research interest lies generally in the area of dietary patterns and chronic diseases including hypertension using controlled feeding study and lifestyle intervention designs. Two major controlled feeding clinical trials that I was involved in include the Dietary Approaches to Stop Hypertension (DASH) Study and the Dietary Approaches to Stop Hypertension-Sodium (DASH-Sodium) Study. In addition to being an active member for the diet committee for DASH, I also function as the
Professor of Medicine
Laura P. Svetkey, MD MHS is Professor of Medicine/Nephrology, Vice Chair for Faculty Development and Diversity in the Department of Medicine, and School of Medicine Faculty Ombudsperson. She is also the Director of Duke’s CTSA-sponsored internal career development award program (KL2) and the Investigator Development Core of Duke’s REACH Equity Disparities Research Center. Dr. Svetkey has over 30 years of experience in the investigation of hypertension, obe
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