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Deep brain stimulation for tremor associated with underlying ataxia syndromes: a case series and discussion of issues.

dc.contributor.author Oyama, G
dc.contributor.author Thompson, A
dc.contributor.author Foote, KD
dc.contributor.author Limotai, N
dc.contributor.author Abd-El-Barr, Muhammad
dc.contributor.author Maling, N
dc.contributor.author Malaty, IA
dc.contributor.author Rodriguez, RL
dc.contributor.author Subramony, SH
dc.contributor.author Ashizawa, T
dc.contributor.author Okun, MS
dc.coverage.spatial United States
dc.date.accessioned 2017-09-26T19:15:34Z
dc.date.available 2017-09-26T19:15:34Z
dc.date.issued 2014
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/25120941
dc.identifier.issn 2160-8288
dc.identifier.uri http://hdl.handle.net/10161/15569
dc.description.abstract BACKGROUND: Deep brain stimulation (DBS) has been utilized to treat various symptoms in patients suffering from movement disorders such as Parkinson's disease, dystonia, and essential tremor. Though ataxia syndromes have not been formally or frequently addressed with DBS, there are patients with ataxia and associated medication refractory tremor or dystonia who may potentially benefit from therapy. METHODS: A retrospective database review was performed, searching for cases of ataxia where tremor and/or dystonia were addressed by utilizing DBS at the University of Florida Center for Movement Disorders and Neurorestoration between 2008 and 2011. Five patients were found who had DBS implantation to address either medication refractory tremor or dystonia. The patient's underlying diagnoses included spinocerebellar ataxia type 2 (SCA2), fragile X associated tremor ataxia syndrome (FXTAS), a case of idiopathic ataxia (ataxia not otherwise specified [NOS]), spinocerebellar ataxia type 17 (SCA17), and a senataxin mutation (SETX). RESULTS: DBS improved medication refractory tremor in the SCA2 and the ataxia NOS patients. The outcome for the FXTAS patient was poor. DBS improved dystonia in the SCA17 and SETX patients, although dystonia did not improve in the lower extremities of the SCA17 patient. All patients reported a transient gait dysfunction postoperatively, and there were no reports of improvement in ataxia-related symptoms. DISCUSSION: DBS may be an option to treat tremor, inclusive of dystonic tremor in patients with underlying ataxia; however, gait and other symptoms may possibly be worsened.
dc.language eng
dc.relation.ispartof Tremor Other Hyperkinet Mov (N Y)
dc.relation.isversionof 10.7916/D8542KQ5
dc.subject SCA17
dc.subject SCA2
dc.subject Tremor
dc.subject deep brain stimulation
dc.subject fragile X syndrome
dc.subject myoclonic dystonia
dc.subject unilateral
dc.title Deep brain stimulation for tremor associated with underlying ataxia syndromes: a case series and discussion of issues.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/25120941
pubs.begin-page 228
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Neurosurgery
pubs.organisational-group School of Medicine
pubs.publication-status Published online
pubs.volume 4


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