B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity.
Abstract
Myasthenia gravis (MG) is a T cell-dependent, B cell-mediated disease. The mechanisms
for loss of self-tolerance in this disease are not well understood, and recently described
regulatory B cell (Breg) subsets have not been thoroughly investigated. B10 cells
are a subset of Bregs identified by the production of the immunosuppressive cytokine,
interleukin-10 (IL-10). B10 cells are known to strongly inhibit B- and T-cell inflammatory
responses in animal models and are implicated in human autoimmunity. In this study,
we examined quantitative and qualitative aspects of B10 cells in acetylcholine receptor
autoantibody positive MG (AChR-MG) patients and healthy controls. We observed reduced
B10 cell frequencies in AChR-MG patients, which inversely correlated with disease
severity. Disease severity also affected the function of B10 cells, as B10 cells in
the moderate/severe group of MG patients were less effective in suppressing CD4 T-cell
proliferation. These results suggest that B10 cell frequencies may be a useful biomarker
of disease severity, and therapeutics designed to restore B10 cell frequencies could
hold promise as a treatment for this disease through restoration of self-tolerance.
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https://hdl.handle.net/10161/15573Published Version (Please cite this version)
10.3389/fneur.2017.00034Publication Info
Yi, John S; Russo, Melissa A; Massey, Janice M; Juel, Vern; Hobson-Webb, Lisa D; Gable,
Karissa; ... Guptill, Jeffrey T (2017). B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated
with Disease Severity. Front Neurol, 8. pp. 34. 10.3389/fneur.2017.00034. Retrieved from https://hdl.handle.net/10161/15573.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Karissa Lorraine Gable
Associate Professor of Neurology
Jeffrey Guptill
Adjunct Associate Professor in the Department of Neurology
Lisa Deneen Hobson-Webb
Professor of Neurology
Trained in neuromuscular medicine, my clinical career has focused on the care of patients
with genetically mediated neuromuscular disorders, rare peripheral neuropathies, and
immune-mediated nerve and muscle disorders and performing high quality electrodiagnostic
testing (nerve conduction studies/electromyography). As a researcher, the core aim
of my work is applying high resolution ultrasound in the care of patients with neuromuscular
diseases. My early work focused on peripheral nerve
Vern Charles Juel
Professor of Neurology
Janice Munn Massey
Professor of Neurology
Clinical Research in Neuromuscular diseases including myasthenia gravis, Lambert-Eaton
myasthenic syndrome, botulinum toxins, electromyography, dystonic disorders including
cervical dystonia (spasmodic torticollis), limb focal dystonia, and blepharospasm.
Shruti Mukund Raja
Assistant Professor of Neurology
Kent James Weinhold
Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery
In addition to their ongoing HIV/AIDS-related research activities, the Weinhold Laboratory
is focused on utilizing a comprehensive repertoire of highly standardized and formerly
validated assay platforms to profile the human immune system in order to identify
immunologic signatures that predict disease outcomes. These ongoing studies span a
broad range of highly relevant clinical arenas, including: 1) cancer (non-small cell
lung cancer, head and neck cancer, glioblastoma neof
John S Yi
Adjunct Assistant Professor in the Department of Surgery
I am an immunologist, with a focus to characterize the immune system in response to
infectious and non-infectious diseases including cancer, HIV, autoimmune disease,
and transplantation. My goals are to identify novel biomarkers/immune signatures that
clinicians can utilize to diagnosis, predict disease outcomes, and determine patients'
response to treatment.
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