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B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity.

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Date
2017
Authors
Yi, John S
Russo, Melissa A
Massey, Janice M
Juel, Vern
Hobson-Webb, Lisa D
Gable, Karissa
Raja, Shruti M
Balderson, Kristina
Weinhold, Kent J
Guptill, Jeffrey T
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Abstract
Myasthenia gravis (MG) is a T cell-dependent, B cell-mediated disease. The mechanisms for loss of self-tolerance in this disease are not well understood, and recently described regulatory B cell (Breg) subsets have not been thoroughly investigated. B10 cells are a subset of Bregs identified by the production of the immunosuppressive cytokine, interleukin-10 (IL-10). B10 cells are known to strongly inhibit B- and T-cell inflammatory responses in animal models and are implicated in human autoimmunity. In this study, we examined quantitative and qualitative aspects of B10 cells in acetylcholine receptor autoantibody positive MG (AChR-MG) patients and healthy controls. We observed reduced B10 cell frequencies in AChR-MG patients, which inversely correlated with disease severity. Disease severity also affected the function of B10 cells, as B10 cells in the moderate/severe group of MG patients were less effective in suppressing CD4 T-cell proliferation. These results suggest that B10 cell frequencies may be a useful biomarker of disease severity, and therapeutics designed to restore B10 cell frequencies could hold promise as a treatment for this disease through restoration of self-tolerance.
Type
Journal article
Subject
AChR
B10
Breg
IL-10
myasthenia gravis
regulatory B cells
Permalink
https://hdl.handle.net/10161/15573
Published Version (Please cite this version)
10.3389/fneur.2017.00034
Publication Info
Yi, John S; Russo, Melissa A; Massey, Janice M; Juel, Vern; Hobson-Webb, Lisa D; Gable, Karissa; ... Guptill, Jeffrey T (2017). B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity. Front Neurol, 8. pp. 34. 10.3389/fneur.2017.00034. Retrieved from https://hdl.handle.net/10161/15573.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Gable

Karissa Lorraine Gable

Associate Professor of Neurology
Guptill

Jeffrey Guptill

Adjunct Associate Professor in the Department of Neurology
Hobson-Webb

Lisa Deneen Hobson-Webb

Professor of Neurology
Trained in neuromuscular medicine, my clinical career has focused on the care of patients with genetically mediated neuromuscular disorders, rare peripheral neuropathies, and immune-mediated nerve and muscle disorders and performing high quality electrodiagnostic testing (nerve conduction studies/electromyography). As a researcher, the core aim of my work is applying high resolution ultrasound in the care of patients with neuromuscular diseases.  My early work focused on peripheral nerve
Juel

Vern Charles Juel

Professor of Neurology
Massey

Janice Munn Massey

Professor of Neurology
Clinical Research in Neuromuscular diseases including myasthenia gravis, Lambert-Eaton myasthenic syndrome, botulinum toxins, electromyography, dystonic disorders including cervical dystonia (spasmodic torticollis), limb focal dystonia, and blepharospasm.
Raja

Shruti Mukund Raja

Assistant Professor of Neurology
Weinhold

Kent James Weinhold

Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery
In addition to their ongoing HIV/AIDS-related research activities, the Weinhold Laboratory is focused on utilizing a comprehensive repertoire of highly standardized and formerly validated assay platforms to profile the human immune system in order to identify immunologic signatures that predict disease outcomes. These ongoing studies span a broad range of highly relevant clinical arenas, including: 1) cancer (non-small cell lung cancer, head and neck cancer, glioblastoma neof
Yi

John S Yi

Adjunct Assistant Professor in the Department of Surgery
I am an immunologist, with a focus to characterize the immune system in response to infectious and non-infectious diseases including cancer, HIV, autoimmune disease, and transplantation. My goals are to identify novel biomarkers/immune signatures that clinicians can utilize to diagnosis, predict disease outcomes, and determine patients' response to treatment. 
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