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B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity.

dc.contributor.author Balderson, Kristina
dc.contributor.author Gable, Karissa Lorraine
dc.contributor.author Guptill, JT
dc.contributor.author Hobson-Webb, Lisa Deneen
dc.contributor.author Juel, Vern Charles
dc.contributor.author Massey, JM
dc.contributor.author Raja, SM
dc.contributor.author Russo, Melissa A
dc.contributor.author Weinhold, Kent James
dc.contributor.author Yi, John S
dc.coverage.spatial Switzerland
dc.date.accessioned 2017-09-28T17:48:29Z
dc.date.available 2017-09-28T17:48:29Z
dc.date.issued 2017
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/28239367
dc.identifier.issn 1664-2295
dc.identifier.uri http://hdl.handle.net/10161/15573
dc.description.abstract Myasthenia gravis (MG) is a T cell-dependent, B cell-mediated disease. The mechanisms for loss of self-tolerance in this disease are not well understood, and recently described regulatory B cell (Breg) subsets have not been thoroughly investigated. B10 cells are a subset of Bregs identified by the production of the immunosuppressive cytokine, interleukin-10 (IL-10). B10 cells are known to strongly inhibit B- and T-cell inflammatory responses in animal models and are implicated in human autoimmunity. In this study, we examined quantitative and qualitative aspects of B10 cells in acetylcholine receptor autoantibody positive MG (AChR-MG) patients and healthy controls. We observed reduced B10 cell frequencies in AChR-MG patients, which inversely correlated with disease severity. Disease severity also affected the function of B10 cells, as B10 cells in the moderate/severe group of MG patients were less effective in suppressing CD4 T-cell proliferation. These results suggest that B10 cell frequencies may be a useful biomarker of disease severity, and therapeutics designed to restore B10 cell frequencies could hold promise as a treatment for this disease through restoration of self-tolerance.
dc.language eng
dc.relation.ispartof Front Neurol
dc.relation.isversionof 10.3389/fneur.2017.00034
dc.subject AChR
dc.subject B10
dc.subject Breg
dc.subject IL-10
dc.subject myasthenia gravis
dc.subject regulatory B cells
dc.title B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/28239367
pubs.begin-page 34
pubs.organisational-group Basic Science Departments
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Clinical Research Institute
pubs.organisational-group Duke Human Vaccine Institute
pubs.organisational-group Immunology
pubs.organisational-group Institutes and Centers
pubs.organisational-group Neurology
pubs.organisational-group Neurology, Neuromuscular Disease
pubs.organisational-group Pathology
pubs.organisational-group School of Medicine
pubs.organisational-group Surgery
pubs.organisational-group Surgery, Surgical Sciences
pubs.publication-status Published online
pubs.volume 8


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