A Foxp2 Mutation Implicated in Human Speech Deficits Alters Sequencing of Ultrasonic Vocalizations in Adult Male Mice.
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Development of proficient spoken language skills is disrupted by mutations of the FOXP2 transcription factor. A heterozygous missense mutation in the KE family causes speech apraxia, involving difficulty producing words with complex learned sequences of syllables. Manipulations in songbirds have helped to elucidate the role of this gene in vocal learning, but findings in non-human mammals have been limited or inconclusive. Here, we performed a systematic study of ultrasonic vocalizations (USVs) of adult male mice carrying the KE family mutation. Using novel statistical tools, we found that Foxp2 heterozygous mice did not have detectable changes in USV syllable acoustic structure, but produced shorter sequences and did not shift to more complex syntax in social contexts where wildtype animals did. Heterozygous mice also displayed a shift in the position of their rudimentary laryngeal motor cortex (LMC) layer-5 neurons. Our findings indicate that although mouse USVs are mostly innate, the underlying contributions of FoxP2 to sequencing of vocalizations are conserved with humans.
Published Version (Please cite this version)10.3389/fnbeh.2016.00197
Publication InfoChabout, J; Dunson, David B; Fisher, SE; Jarvis, Erich David; Patel, SR; Radden, T; & Sarkar, Abhra (2016). A Foxp2 Mutation Implicated in Human Speech Deficits Alters Sequencing of Ultrasonic Vocalizations in Adult Male Mice. Front Behav Neurosci, 10. pp. 197. 10.3389/fnbeh.2016.00197. Retrieved from http://hdl.handle.net/10161/15592.
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Arts and Sciences Professor of Statistical Science
Development of novel approaches for representing and analyzing complex data. A particular focus is on methods that incorporate geometric structure (both known and unknown) and on probabilistic approaches to characterize uncertainty. In addition, a big interest is in scalable algorithms and in developing approaches with provable guarantees.This fundamental work is directly motivated by applications in biomedical research, network data analysis, neuroscience, genomics, ecol
Adjunct Professor in the Dept. of Neurobiology
Dr. Jarvis' laboratory studies the neurobiology of vocal communication. Emphasis is placed on the molecular pathways involved in the perception and production of learned vocalizations. They use an integrative approach that combines behavioral, anatomical, electrophysiological and molecular biological techniques. The main animal model used is songbirds, one of the few vertebrate groups that evolved the ability to learn vocalizations. The generality of the discoveries is tested in other vocal
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