Editorial overview: Metabolism of T cells: integrating nutrients, signals, and cell fate
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Published Version (Please cite this version)10.1016/j.coi.2017.06.062
Publication InfoMacIver, Nancie Jo; & Rathmell, Jeffrey C (2017). Editorial overview: Metabolism of T cells: integrating nutrients, signals, and cell fate. CURRENT OPINION IN IMMUNOLOGY, 46. pp. VIII-XI. 10.1016/j.coi.2017.06.062. Retrieved from http://hdl.handle.net/10161/15605.
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Associate Professor of Pediatrics
My laboratory is broadly interested in how large changes in nutritional status (e.g. malnutrition or obesity) influence T cell immunity. Malnutrition can lead to immunodeficiency and increased risk of infection, whereas obesity is associated with inflammation that promotes multiple diseases including autoimmunity, type 2 diabetes, and cardiovascular disease. We have identified the adipocyte-secreted hormone leptin as a critical link between nutrition and immunity. Leptin is
Adjunct Associate Professor in the Department of Pharmacology and Cancer Biology
My laboratory studies the mechanisms and role of glucose metabolism in lymphocyte survival and activation. We have found that dramatic increases in glucose metabolism are necessary for lymphocytes to survive and mount immune responses. Excessive glucose metabolism, however, can lead to T cell hyperactivation and autoimmunity. A key mechanism for control of lymphocyte glucose metabolism is regulation of glucose uptake by the glucose transporter, Glut1. Interestingly, upregulation of Glut1
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