Enhanced recovery protocols for colorectal surgery and postoperative renal function: a retrospective review.
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BACKGROUND: While enhanced recovery protocols (ERPs) reduce physiologic stress and improve outcomes in general, their effects on postoperative renal function have not been directly studied. METHODS: Patients undergoing major colorectal surgery under ERP (February 2010 to March 2013) were compared with a traditional care control group (October 2004 October 2007) at a single institution. Multivariable regression models examined the association of ERP with postoperative creatinine changes and incidence of postoperative acute kidney dysfunction (based on the Risk, Injury, Failure, Loss, and End-stage renal disease criteria). RESULTS: Included were 1054 patients: 590 patients underwent surgery with ERP and 464 patients without ERP. Patient demographics were not significantly different. Higher rates of neoplastic and inflammatory bowel disease surgical indications were found in the ERP group (81 vs. 74%, p = 0.045). Patients in the ERP group had more comorbidities (ASA ≥ 3) (62 vs. 40%, p < 0.001). In unadjusted analysis, postoperative creatinine increase was slightly higher in the ERP group compared with control (median 0.1 vs. 0 mg/dL, p < 0.001), but levels of postoperative acute kidney injury were similar in both groups (p = 0.998). After adjustment with multivariable regression, postoperative changes in creatinine were similar in ERP vs. control (p = 0.25). CONCLUSIONS: ERP in colorectal surgery is not associated with a clinically significant increase in postoperative creatinine or incidence of postoperative kidney injury. Our results support the safety of ERPs in colorectal surgery and may promote expanding implementation of these protocols. TRIAL REGISTRATION: Not applicable, prospective data collection and retrospective chart review only.
Published Version (Please cite this version)10.1186/s13741-017-0069-0
Publication InfoAdam, MA; Grant, Stuart Alan; Horres, C Russell III; Miller, Timothy Ellis; Moon, Richard Edward; Sun, Zhifei; & Thacker, Julie K Marosky (2017). Enhanced recovery protocols for colorectal surgery and postoperative renal function: a retrospective review. Perioper Med (Lond), 6. pp. 13. 10.1186/s13741-017-0069-0. Retrieved from https://hdl.handle.net/10161/15693.
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Professor of Anesthesiology
My research interests include regional anesthesia, acute pain management, and ambulatory anesthesia. Our regional anesthesia group have particular interest in resident education and ultrasound guided nerve block. We also have an interest in the use of continuous peripheral catheter systems and liposomal drug delivery systems for prolonged post operative analgesia. We also investigate the effects of regional anesthesia on patient outcomes. My ambulatory anesthesia research interes
This author no longer has a Scholars@Duke profile, so the information shown here reflects their Duke status at the time this item was deposited.
Associate Professor of Anesthesiology
Clinical and research interests are Enhanced Recovery and Perioperative Medicine; with particular interests in fluid management, and perioperative optimization of the high-risk non-cardiac surgery patient.
Professor of Anesthesiology
Research interests include the study of cardiorespiratory function in humans exposed to environmental conditions ranging from 200 feet of seawater depth to high altitude, gas exchange during diving, the pathophysiology of high altitude pulmonary edema, the effect of anesthesia and postoperative analgesia on pulmonary function and monitoring of tissue oxygenation. Ongoing human studies include the use of fractals to study breathing patterns during environmental and perioperative stress, mechanism
Associate Professor of Surgery
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