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Profile of pazopanib and its potential in the treatment of epithelial ovarian cancer.

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Profile of pazopanib and its potential in the treatment of epithelial ovarian cancer.pdf
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Profile of pazopanib and its potential in the treatment of epithelial ovarian cancer.pdf
900.3 Kb
Date
2014
Authors
Davidson, Brittany A
Secord, Angeles Alvarez
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Abstract
Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. Recently, clinical trials have focused on novel antiangiogenic agents in combination with chemotherapy or alone in women with primary and recurrent ovarian cancer. Antiangiogenic agents include monoclonal antibodies, tyrosine-kinase inhibitors, and peptibodies. Many of these agents, including bevacizumab, pazopanib, nintedanib, cediranib, and trebananib, have been evaluated in randomized Phase III clinical trials, and all have demonstrated a progression-free survival (PFS) benefit. Specifically, maintenance pazopanib was shown to improve PFS in women with newly diagnosed EOC. Pazopanib, an oral TKI, inhibits several kinase receptors, including those for vascular endothelial growth factor (-1,-2,-3), platelet-derived growth factor (-α and -β), and fibroblast growth factor. It also targets stem cell-factor receptor (c-kit), interleukin 2-inducible T-cell kinase, lymphocyte-specific protein tyrosine kinase, and colony-stimulating factor 1 receptor. Pazopanib has been investigated in several Phase II and III clinical trials, with results indicating a potential role in the management of EOC. This article provides an overview of pazopanib in the treatment of EOC.
Type
Journal article
Subject
antiangiogenic agents
ovarian carcinoma
pazopanib
Permalink
https://hdl.handle.net/10161/15735
Published Version (Please cite this version)
10.2147/IJWH.S49781
Publication Info
Davidson, Brittany A; & Secord, Angeles Alvarez (2014). Profile of pazopanib and its potential in the treatment of epithelial ovarian cancer. Int J Womens Health, 6. pp. 289-300. 10.2147/IJWH.S49781. Retrieved from https://hdl.handle.net/10161/15735.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Davidson

Brittany A Davidson

Associate Professor of Obstetrics and Gynecology
Secord

Angeles Alvarez Secord

Professor of Obstetrics and Gynecology
My primary research interest has focused on on novel therapeutics, biomarkers and clinical trial development for ovarian and endometrial cancer. My fundamental goal is to develop a strong translational research program at Duke University in the Gynecologic Oncology Division, where knowledge we glean from our basic science research can be incorporated into our clinical trial program. Specifically, my focus is on biologic therapy and molecular biomarkers to direct therapy in patients with ovari
Alphabetical list of authors with Scholars@Duke profiles.
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