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S-100β and Antioxidant Capacity in Cerebrospinal Fluid during and after Thoracic Endovascular Aortic Repair.

dc.contributor.author Nandate, K
dc.contributor.author Sharma, D
dc.contributor.author Olivar, H
dc.contributor.author Hallman, M
dc.contributor.author Ramaiah, R
dc.contributor.author Joffe, A
dc.contributor.author Roche, Anthony Michael
dc.contributor.author Krishnamoorthy, Vijay
dc.coverage.spatial United States
dc.date.accessioned 2017-11-09T18:52:44Z
dc.date.available 2017-11-09T18:52:44Z
dc.date.issued 2017
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/28740858
dc.identifier.issn 2356-7872
dc.identifier.uri https://hdl.handle.net/10161/15741
dc.description.abstract BACKGROUND: Thoracic Endovascular Aortic Repair (TEVAR) has substantially decreased the mortality and major complications from aortic surgery. However, neurological complications such as spinal cord ischemia may still occur after TEVAR. S-100β is a biomarker of central nervous system injury, and oxidant injury plays an important role in neurological injury. In this pilot study, we examined the trends of S-100β and antioxidant capacity in the CSF during and after TEVAR. METHODS: We recruited 10 patients who underwent elective TEVAR. CSF samples were collected through a lumbar catheter at the following time points: before the start of surgery (T0) and immediately (T1) and 24 (T2) and 48 hours (T3) after the deployment of the aortic stent. S-100β and CSF antioxidant capacity were analyzed with the use of commercially available kits. RESULTS: We observed that the level of S-100β in all of the subjects at 24 hours after the deployment of the aortic stent (T2) increased. However, the levels of S-100β at T1 and T3 were comparable to the baseline value. The antioxidant capacity remained unchanged. No patient had a clinical neurologic complication. CONCLUSIONS: Our observations may indicate biochemical/subclinical central nervous system injury attributable to the deployment of the aortic stent.
dc.language eng
dc.relation.ispartof Int Sch Res Notices
dc.relation.isversionof 10.1155/2017/6875195
dc.title S-100β and Antioxidant Capacity in Cerebrospinal Fluid during and after Thoracic Endovascular Aortic Repair.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/28740858
pubs.begin-page 6875195
pubs.organisational-group Anesthesiology
pubs.organisational-group Anesthesiology, Critical Care Medicine
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group School of Medicine
pubs.publication-status Published online
pubs.volume 2017


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