dc.contributor.author |
Ramakrishnan, Arjun |
|
dc.contributor.author |
Byun, Yoon Woo |
|
dc.contributor.author |
Rand, Kyle |
|
dc.contributor.author |
Pedersen, Christian E |
|
dc.contributor.author |
Lebedev, Mikhail A |
|
dc.contributor.author |
Nicolelis, Miguel AL |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2017-11-27T17:13:41Z |
|
dc.date.available |
2017-11-27T17:13:41Z |
|
dc.date.issued |
2017-06-13 |
|
dc.identifier |
https://www.ncbi.nlm.nih.gov/pubmed/28559307 |
|
dc.identifier |
1703668114 |
|
dc.identifier.uri |
https://hdl.handle.net/10161/15773 |
|
dc.description.abstract |
Rewards are known to influence neural activity associated with both motor preparation
and execution. This influence can be exerted directly upon the primary motor (M1)
and somatosensory (S1) cortical areas via the projections from reward-sensitive dopaminergic
neurons of the midbrain ventral tegmental areas. However, the neurophysiological manifestation
of reward-related signals in M1 and S1 are not well understood. Particularly, it is
unclear how the neurons in these cortical areas multiplex their traditional functions
related to the control of spatial and temporal characteristics of movements with the
representation of rewards. To clarify this issue, we trained rhesus monkeys to perform
a center-out task in which arm movement direction, reward timing, and magnitude were
manipulated independently. Activity of several hundred cortical neurons was simultaneously
recorded using chronically implanted microelectrode arrays. Many neurons (9-27%) in
both M1 and S1 exhibited activity related to reward anticipation. Additionally, neurons
in these areas responded to a mismatch between the reward amount given to the monkeys
and the amount they expected: A lower-than-expected reward caused a transient increase
in firing rate in 60-80% of the total neuronal sample, whereas a larger-than-expected
reward resulted in a decreased firing rate in 20-35% of the neurons. Moreover, responses
of M1 and S1 neurons to reward omission depended on the direction of movements that
led to those rewards. These observations suggest that sensorimotor cortical neurons
corepresent rewards and movement-related activity, presumably to enable reward-based
learning.
|
|
dc.language |
eng |
|
dc.publisher |
Proceedings of the National Academy of Sciences |
|
dc.relation.ispartof |
Proc Natl Acad Sci U S A |
|
dc.relation.isversionof |
10.1073/pnas.1703668114 |
|
dc.subject |
motor cortex |
|
dc.subject |
multichannel recording |
|
dc.subject |
prediction error |
|
dc.subject |
primate |
|
dc.subject |
reward |
|
dc.title |
Cortical neurons multiplex reward-related signals along with sensory and motor information. |
|
dc.type |
Journal article |
|
duke.contributor.id |
Lebedev, Mikhail A|0299976 |
|
duke.contributor.id |
Nicolelis, Miguel AL|0099178 |
|
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/28559307 |
|
pubs.begin-page |
E4841 |
|
pubs.end-page |
E4850 |
|
pubs.issue |
24 |
|
pubs.organisational-group |
Basic Science Departments |
|
pubs.organisational-group |
Biomedical Engineering |
|
pubs.organisational-group |
Clinical Science Departments |
|
pubs.organisational-group |
Duke |
|
pubs.organisational-group |
Duke Institute for Brain Sciences |
|
pubs.organisational-group |
Institutes and Provost's Academic Units |
|
pubs.organisational-group |
Neurobiology |
|
pubs.organisational-group |
Neurology |
|
pubs.organisational-group |
Neurology, Behavioral Neurology |
|
pubs.organisational-group |
Orthopaedics |
|
pubs.organisational-group |
Pratt School of Engineering |
|
pubs.organisational-group |
Psychology and Neuroscience |
|
pubs.organisational-group |
School of Medicine |
|
pubs.organisational-group |
Staff |
|
pubs.organisational-group |
Temp group - logins allowed |
|
pubs.organisational-group |
Trinity College of Arts & Sciences |
|
pubs.organisational-group |
University Institutes and Centers |
|
pubs.publication-status |
Published |
|
pubs.volume |
114 |
|
dc.identifier.eissn |
1091-6490 |
|