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Microarray-Based Phospho-Proteomic Profiling of Complex Biological Systems.

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Date
2016-04
Authors
Goodwin, C Rory
Woodard, Crystal L
Zhou, Xin
Pan, Jianbo
Olivi, Alessandro
Xia, Shuli
Bettegowda, Chetan
Sciubba, Daniel M
Pevsner, Jonathan
Zhu, Heng
Laterra, John
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(11 total)
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Abstract
Protein microarray technology has been successfully used for identifying substrates of purified activated kinases. We used protein microarrays to globally interrogate the effects of PTEN and Akt activity on the phospho-kinome of in vitro and in vivo glioma models and validated results in clinical pathological specimens. Whole cell lysates extracted from tumor samples can be applied to human kinome chip microarrays to profile the global kinase phosphorylation patterns in a high-throughput manner and identify novel substrates inherent to the tumor cell and the interactions with tumor microenvironment. Our findings identify a novel microarray-based method for assessing intracellular signaling events applicable to human oncogenesis and other pathophysiologic states.
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Journal article
Permalink
https://hdl.handle.net/10161/15820
Published Version (Please cite this version)
10.1016/j.tranon.2016.02.001
Publication Info
Goodwin, C Rory; Woodard, Crystal L; Zhou, Xin; Pan, Jianbo; Olivi, Alessandro; Xia, Shuli; ... Laterra, John (2016). Microarray-Based Phospho-Proteomic Profiling of Complex Biological Systems. Transl Oncol, 9(2). pp. 124-129. 10.1016/j.tranon.2016.02.001. Retrieved from https://hdl.handle.net/10161/15820.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Goodwin

Courtney Rory Goodwin

Assistant Professor of Neurosurgery
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