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Beta-cell sensitivity to glucose is impaired after gastric bypass surgery.

dc.contributor.author Salehi, M
dc.contributor.author Gastaldelli, A
dc.contributor.author D'Alessio, David A
dc.coverage.spatial England
dc.date.accessioned 2017-12-18T19:58:31Z
dc.date.available 2017-12-18T19:58:31Z
dc.date.issued 2017-11-20
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/29152839
dc.identifier.uri http://hdl.handle.net/10161/15909
dc.description.abstract AIMS: Patients with Roux-en-Y gastric bypass surgery (GB) have exaggerated postprandial insulin secretion, which has been attributed to increased meal glucose appearance and enhanced incretin effect. Here we sought to determine β-cell glucose sensitivity in the absence of meal stimulation and insulinotropic gut factors. MATERIALS AND METHODS: Twelve non-diabetic subjects with prior GB, and 7 matched non-surgical controls with normal glucose tolerance were studied. Blood glucose and insulin secretion rates were measured during a graded glucose infusion at increasing and then decreasing rates. Insulin sensitivity (SI ) and glucose effectiveness (SG ) were determined by the minimal model. RESULTS: The GB subjects had comparable SI to the controls. The GB subjects had relative hyperglycemia during highest dose of glucose infusion associated with significantly reduced β-cell glucose sensitivity throughout both step-up (GB: 34±6, CN: 82±9 pmol.min-1 .mM-1 .L, p<0.0001) and step-down (GB: 31±6, CN: 74±9 pmol.min-1 .mM-1 .L, p<0.0001) phases of the glucose infusion. The GB subjects also had reduced SG (GB: 0.04±0.00, CN: 0.07±0.01 min-1 , p = 0.004). CONCLUSION: In the absence of enteric stimuli β-cell sensitivity to changes in glycemia is blunted among individuals with GB, indicating a significant shift in a fundamental property of β-cell function several years after surgery.
dc.language eng
dc.relation.ispartof Diabetes Obes Metab
dc.relation.isversionof 10.1111/dom.13165
dc.subject gastric bypass surgery
dc.subject glucose tolerance
dc.subject β-cell glucose sensitivity
dc.title Beta-cell sensitivity to glucose is impaired after gastric bypass surgery.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/29152839
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Molecular Physiology Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Endocrinology, Metabolism, and Nutrition
pubs.organisational-group School of Medicine
pubs.organisational-group Temp group - logins allowed
pubs.publication-status Published online
dc.identifier.eissn 1463-1326


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