White Matter Changes Related to Subconcussive Impact Frequency during a Single Season of High School Football.
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BACKGROUND AND PURPOSE: The effect of exposing the developing brain of a high school football player to subconcussive impacts during a single season is unknown. The purpose of this pilot study was to use diffusion tensor imaging to assess white matter changes during a single high school football season, and to correlate these changes with impacts measured by helmet accelerometer data and neurocognitive test scores collected during the same period. MATERIALS AND METHODS: Seventeen male athletes (mean age, 16 ± 0.73 years) underwent MR imaging before and after the season. Changes in fractional anisotropy across the white matter skeleton were assessed with Tract-Based Spatial Statistics and ROI analysis. RESULTS: The mean number of impacts over a 10-g threshold sustained was 414 ± 291. Voxelwise analysis failed to show significant changes in fractional anisotropy across the season or a correlation with impact frequency, after correcting for multiple comparisons. ROI analysis showed significant (P < .05, corrected) decreases in fractional anisotropy in the fornix-stria terminalis and cingulum hippocampus, which were related to impact frequency. The effects were strongest in the fornix-stria terminalis, where decreases in fractional anisotropy correlated with worsening visual memory. CONCLUSIONS: Our findings suggest that subclinical neurotrauma related to participation in American football may result in white matter injury and that alterations in white matter tracts within the limbic system may be detectable after only 1 season of play at the high school level.
Published Version (Please cite this version)10.3174/ajnr.A5489
Publication InfoKuzminski, SJ; Clark, MD; Fraser, MA; Haswell, CC; Morey, RA; Liu, C; ... Petrella, JR (2017). White Matter Changes Related to Subconcussive Impact Frequency during a Single Season of High School Football. AJNR Am J Neuroradiol. 10.3174/ajnr.A5489. Retrieved from https://hdl.handle.net/10161/15942.
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Associate Professor of Radiology
Magnetic Resonance Imaging (MRI) and its translational applications * Diffusion weighted imaging * Generalized Diffusion Tensor Imaging * Ultra-high field imaging * Image acquisition and reconstruction * High resolution and high speed imaging * Image-contrast mechanism
This author no longer has a Scholars@Duke profile, so the information shown here reflects their Duke status at the time this item was deposited.
Associate Professor of Psychiatry and Behavioral Sciences
Research in my lab is focused on brain changes associated with posttraumatic stress disorder (PTSD), traumatic brain injury (TBI), and other neuropsychiatric disorders. We apply several advanced methods for understanding brain function including functional MRI, structural MRI, diffusion tensor imaging, and genetic effects.
Professor of Radiology
- Quantitating and modeling physiologic processes in normal and diseased states in the central nervous system through the use of imaging - Application and development of advanced MR imaging technologies (e.g., diffusion, perfusion and fMRI) as well as advanced image processing and analysis techniques - Elucidating the functional unpinnings of cognitive impairment in early stage Alzheimer's disease - Development of functional imaging biomarkers for early diagnosis and monitoring
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