Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume.
Repository Usage Stats
Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19-79 years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function.
Diffusion tensor imaging
Magnetic resonance imaging
Diffusion Tensor Imaging
Magnetic Resonance Imaging
Published Version (Please cite this version)10.1016/j.neurobiolaging.2017.01.027
Publication InfoMadden, David J; Parks, Emily L; Tallman, Catherine W; Boylan, Maria A; Hoagey, David A; Cocjin, Sally B; ... Diaz, Michele T (2017). Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume. Neurobiol Aging, 54. pp. 199-213. 10.1016/j.neurobiolaging.2017.01.027. Retrieved from https://hdl.handle.net/10161/15954.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
More InfoShow full item record
Adjunct Associate Professor in the Department of Radiology
Dr. Chen is a magnetic resonance imaging (MRI) physicist with research interest in fast image acquisition methodology, pulse sequence design, MRI artifact correction, and application of MRI to studies of neurological diseases. He has been developing novel high-resolution imaging protocols and analysis procedures for mapping structural and functional connectivity of brains. More generally, Dr. Chen's research involves the application of MRI in translational contexts. He has been serving as the pr
Medical Instructor in the Department of Psychiatry and Behavioral Sciences
Professor of Medical Psychology in the Department of Psychiatry and Behavioral Sciences
My research focuses primarily on the cognitive neuroscience of aging: the investigation of age-related changes in perception, attention, and memory, using both behavioral measures and neuroimaging techniques, including positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and diffusion tensor imaging (DTI). The behavioral measures have focused on reaction time, with the goal of distinguishing age-related changes in specific cognitive abilities from mo
Research Assistant, Ph D Student
Associate Professor in Psychiatry and Behavioral Sciences
Alphabetical list of authors with Scholars@Duke profiles.