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    Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume.

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    Date
    2017-06
    Authors
    Boylan, MA
    Chen, N-K
    Chou, Ying-hui
    Cocjin, SB
    Diaz, Michele Theresa
    Hoagey, DA
    Honig, JA
    Johnson, MA
    Madden, David Joseph
    Monge, Zachary
    Packard, LE
    Parks, EL
    Potter, Guy Glenn
    Siciliano, RE
    Tallman, CW
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    (15 total)
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    Abstract
    Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19-79 years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function.
    Type
    Journal article
    Subject
    Cognition
    Cortex
    Diffusion tensor imaging
    Magnetic resonance imaging
    Mediation
    Adult
    Aged
    Cognition
    Cognitive Aging
    Diffusion Tensor Imaging
    Executive Function
    Female
    Humans
    Magnetic Resonance Imaging
    Male
    Middle Aged
    Rest
    Sensorimotor Cortex
    White Matter
    Permalink
    https://hdl.handle.net/10161/15954
    Published Version (Please cite this version)
    10.1016/j.neurobiolaging.2017.01.027
    Publication Info
    Boylan, MA; Chen, N-K; Chou, Ying-hui; Cocjin, SB; Diaz, Michele Theresa; Hoagey, DA; ... Tallman, CW (2017). Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume. Neurobiol Aging, 54. pp. 199-213. 10.1016/j.neurobiolaging.2017.01.027. Retrieved from https://hdl.handle.net/10161/15954.
    This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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    Scholars@Duke

    Ying-hui Chou

    Medical Instructor in the Department of Psychiatry and Behavioral Sciences
    Madden

    David Joseph Madden

    Professor of Medical Psychology in the Department of Psychiatry and Behavioral Sciences
    My research focuses primarily on the cognitive neuroscience of aging: the investigation of age-related changes in perception, attention, and memory, using both behavioral measures and neuroimaging techniques, including positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and diffusion tensor imaging (DTI). The behavioral measures have focused on reaction time, with the goal of distinguishing age-related changes in specific cognitive abilities from mo

    Zachary Monge

    Student
    Potter

    Guy Glenn Potter

    Associate Professor in Psychiatry and Behavioral Sciences
    Alphabetical list of authors with Scholars@Duke profiles.
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    Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy

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