Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume.
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Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19-79 years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function.
Diffusion tensor imaging
Magnetic resonance imaging
Diffusion Tensor Imaging
Magnetic Resonance Imaging
Published Version (Please cite this version)10.1016/j.neurobiolaging.2017.01.027
Publication InfoBoylan, MA; Chen, N-K; Chou, Ying-hui; Cocjin, SB; Diaz, Michele Theresa; Hoagey, DA; ... Tallman, CW (2017). Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume. Neurobiol Aging, 54. pp. 199-213. 10.1016/j.neurobiolaging.2017.01.027. Retrieved from https://hdl.handle.net/10161/15954.
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Medical Instructor in the Department of Psychiatry and Behavioral Sciences
Professor of Medical Psychology in the Department of Psychiatry and Behavioral Sciences
My research focuses primarily on the cognitive neuroscience of aging: the investigation of age-related changes in perception, attention, and memory, using both behavioral measures and neuroimaging techniques, including positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and diffusion tensor imaging (DTI). The behavioral measures have focused on reaction time, with the goal of distinguishing age-related changes in specific cognitive abilities from mo
Associate Professor in Psychiatry and Behavioral Sciences
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