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Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume.

dc.contributor.author Madden, David J
dc.contributor.author Parks, Emily L
dc.contributor.author Tallman, Catherine W
dc.contributor.author Boylan, Maria A
dc.contributor.author Hoagey, David A
dc.contributor.author Cocjin, Sally B
dc.contributor.author Packard, Lauren E
dc.contributor.author Johnson, Micah A
dc.contributor.author Chou, Ying-Hui
dc.contributor.author Potter, Guy G
dc.contributor.author Chen, Nan-Kuei
dc.contributor.author Siciliano, Rachel E
dc.contributor.author Monge, Zachary A
dc.contributor.author Honig, Jesse A
dc.contributor.author Diaz, Michele T
dc.coverage.spatial United States
dc.date.accessioned 2018-01-03T16:07:00Z
dc.date.available 2018-01-03T16:07:00Z
dc.date.issued 2017-06
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/28389085
dc.identifier S0197-4580(17)30096-9
dc.identifier.uri https://hdl.handle.net/10161/15954
dc.description.abstract Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19-79 years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function.
dc.language eng
dc.publisher Elsevier BV
dc.relation.ispartof Neurobiol Aging
dc.relation.isversionof 10.1016/j.neurobiolaging.2017.01.027
dc.subject Cognition
dc.subject Cortex
dc.subject Diffusion tensor imaging
dc.subject Magnetic resonance imaging
dc.subject Mediation
dc.subject Adult
dc.subject Aged
dc.subject Cognition
dc.subject Cognitive Aging
dc.subject Diffusion Tensor Imaging
dc.subject Executive Function
dc.subject Female
dc.subject Humans
dc.subject Magnetic Resonance Imaging
dc.subject Male
dc.subject Middle Aged
dc.subject Rest
dc.subject Sensorimotor Cortex
dc.subject White Matter
dc.title Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume.
dc.type Journal article
duke.contributor.id Madden, David J|0117007
duke.contributor.id Parks, Emily L|0513252
duke.contributor.id Chou, Ying-Hui|0558717
duke.contributor.id Potter, Guy G|0267475
duke.contributor.id Chen, Nan-Kuei|0458122
duke.contributor.id Monge, Zachary A|0676418
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/28389085
pubs.begin-page 199
pubs.end-page 213
pubs.organisational-group Center for Cognitive Neuroscience
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Duke-UNC Center for Brain Imaging and Analysis
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Psychiatry & Behavioral Sciences
pubs.organisational-group Psychiatry & Behavioral Sciences, Brain Stimulation and Neurophysiology
pubs.organisational-group Psychiatry & Behavioral Sciences, Geriatric Behavioral Health
pubs.organisational-group Psychology and Neuroscience
pubs.organisational-group Radiology
pubs.organisational-group School of Medicine
pubs.organisational-group Student
pubs.organisational-group Temp group - logins allowed
pubs.organisational-group Trinity College of Arts & Sciences
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 54
dc.identifier.eissn 1558-1497
duke.contributor.orcid Madden, David J|0000-0003-2815-6552


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