Frontoparietal activation during visual conjunction search: Effects of bottom-up guidance and adult age.
Abstract
We conducted functional magnetic resonance imaging (fMRI) with a visual search paradigm
to test the hypothesis that aging is associated with increased frontoparietal involvement
in both target detection and bottom-up attentional guidance (featural salience). Participants
were 68 healthy adults, distributed continuously across 19 to 78 years of age. Frontoparietal
regions of interest (ROIs) were defined from resting-state scans obtained prior to
task-related fMRI. The search target was defined by a conjunction of color and orientation.
Each display contained one item that was larger than the others (i.e., a size singleton)
but was not informative regarding target identity. Analyses of search reaction time
(RT) indicated that bottom-up attentional guidance from the size singleton (when coincident
with the target) was relatively constant as a function of age. Frontoparietal fMRI
activation related to target detection was constant as a function of age, as was the
reduction in activation associated with salient targets. However, for individuals
35 years of age and older, engagement of the left frontal eye field (FEF) in bottom-up
guidance was more prominent than for younger individuals. Further, the age-related
differences in left FEF activation were a consequence of decreasing resting-state
functional connectivity in visual sensory regions. These findings indicate that age-related
compensatory effects may be expressed in the relation between activation and behavior,
rather than in the magnitude of activation, and that relevant changes in the activation-RT
relation may begin at a relatively early point in adulthood. Hum Brain Mapp 38:2128-2149,
2017. © 2017 Wiley Periodicals, Inc.
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Journal articlePermalink
https://hdl.handle.net/10161/15955Published Version (Please cite this version)
10.1002/hbm.23509Publication Info
Madden, David J; Parks, Emily L; Tallman, Catherine W; Boylan, Maria A; Hoagey, David
A; Cocjin, Sally B; ... Diaz, Michele T (2017). Frontoparietal activation during visual conjunction search: Effects of bottom-up guidance
and adult age. Hum Brain Mapp, 38(4). pp. 2128-2149. 10.1002/hbm.23509. Retrieved from https://hdl.handle.net/10161/15955.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Nan-kuei Chen
Adjunct Associate Professor in the Department of Radiology
Dr. Chen is a magnetic resonance imaging (MRI) physicist with research interest in
fast image acquisition methodology, pulse sequence design, MRI artifact correction,
and application of MRI to studies of neurological diseases. He has been developing
novel high-resolution imaging protocols and analysis procedures for mapping structural
and functional connectivity of brains. More generally, Dr. Chen's research involves
the application of MRI in translational contexts. He has been serving as the pr
Ying-hui Chou
Medical Instructor in the Department of Psychiatry and Behavioral Sciences
David Joseph Madden
Professor in Psychiatry and Behavioral Sciences
My research focuses primarily on the cognitive neuroscience of aging: the investigation
of age-related changes in perception, attention, and memory, using both behavioral
measures and neuroimaging techniques, including positron emission tomography (PET),
functional magnetic resonance imaging (fMRI), and diffusion tensor imaging (DTI).
The behavioral measures have focused on reaction time, with the goal of distinguishing
age-related changes in specific cognitive abilities from mo
Zachary Monge
Research Assistant, Ph D Student
Emily L Parks
Lecturing Fellow of Thompson Writing Program
Guy Glenn Potter
Associate Professor in Psychiatry and Behavioral Sciences
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