Association between increased magnetic susceptibility of deep gray matter nuclei and decreased motor function in healthy adults.
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In the human brain, iron is more prevalent in gray matter than in white matter, and deep gray matter structures, particularly the globus pallidus, putamen, caudate nucleus, substantia nigra, red nucleus, and dentate nucleus, exhibit especially high iron content. Abnormally elevated iron levels have been found in various neurodegenerative diseases. Additionally, iron overload and related neurodegeneration may also occur during aging, but the functional consequences are not clear. In this study, we explored the correlation between magnetic susceptibility--a surrogate marker of brain iron--of these gray matter structures with behavioral measures of motor and cognitive abilities, in 132 healthy adults aged 40-83 years. Latent variables corresponding to manual dexterity and executive functions were obtained using factor analysis. The factor scores for manual dexterity declined significantly with increasing age. Independent of gender, age, and global cognitive function, increasing magnetic susceptibility in the globus pallidus and red nuclei was associated with decreasing manual dexterity. This finding suggests the potential value of magnetic susceptibility, a non-invasive quantitative imaging marker of iron, for the study of iron-related brain function changes.
Aged, 80 and over
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Published Version (Please cite this version)10.1016/j.neuroimage.2014.10.009
Publication InfoLi, Wei; Langkammer, Christian; Chou, Ying-Hui; Petrovic, Katja; Schmidt, Reinhold; Song, Allen W; ... Liu, Chunlei (2015). Association between increased magnetic susceptibility of deep gray matter nuclei and decreased motor function in healthy adults. Neuroimage, 105. pp. 45-52. 10.1016/j.neuroimage.2014.10.009. Retrieved from https://hdl.handle.net/10161/15958.
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Medical Instructor in the Department of Psychiatry and Behavioral Sciences
Associate Professor of Radiology
Magnetic Resonance Imaging (MRI) and its translational applications * Diffusion weighted imaging * Generalized Diffusion Tensor Imaging * Ultra-high field imaging * Image acquisition and reconstruction * High resolution and high speed imaging * Image-contrast mechanism
This author no longer has a Scholars@Duke profile, so the information shown here reflects their Duke status at the time this item was deposited.
Professor of Medical Psychology in the Department of Psychiatry and Behavioral Sciences
My research focuses primarily on the cognitive neuroscience of aging: the investigation of age-related changes in perception, attention, and memory, using both behavioral measures and neuroimaging techniques, including positron emission tomography (PET), functional magnetic resonance imaging (fMRI), and diffusion tensor imaging (DTI). The behavioral measures have focused on reaction time, with the goal of distinguishing age-related changes in specific cognitive abilities from mo
Professor in Radiology
The research in our lab is concerned with advancing structural and functional MRI methodologies (e.g. fast and high-resolution imaging techniques) for human brain imaging. We also aim to improve our understanding of functional brain signals, including spatiotemporal characterizations of the blood oxygenation level dependent contrast and alternative contrast mechanisms that are more directly linked to the neuronal activities. Additional effort is invested in applying and validating the de
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