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Association between increased magnetic susceptibility of deep gray matter nuclei and decreased motor function in healthy adults.

dc.contributor.author Chou, Ying-hui
dc.contributor.author Langkammer, C
dc.contributor.author Li, W
dc.contributor.author Liu, C
dc.contributor.author Madden, David Joseph
dc.contributor.author Petrovic, K
dc.contributor.author Ropele, S
dc.contributor.author Schmidt, R
dc.contributor.author Song, AW
dc.coverage.spatial United States
dc.date.accessioned 2018-01-03T16:18:31Z
dc.date.available 2018-01-03T16:18:31Z
dc.date.issued 2015-01-15
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/25315786
dc.identifier S1053-8119(14)00820-9
dc.identifier.uri https://hdl.handle.net/10161/15958
dc.description.abstract In the human brain, iron is more prevalent in gray matter than in white matter, and deep gray matter structures, particularly the globus pallidus, putamen, caudate nucleus, substantia nigra, red nucleus, and dentate nucleus, exhibit especially high iron content. Abnormally elevated iron levels have been found in various neurodegenerative diseases. Additionally, iron overload and related neurodegeneration may also occur during aging, but the functional consequences are not clear. In this study, we explored the correlation between magnetic susceptibility--a surrogate marker of brain iron--of these gray matter structures with behavioral measures of motor and cognitive abilities, in 132 healthy adults aged 40-83 years. Latent variables corresponding to manual dexterity and executive functions were obtained using factor analysis. The factor scores for manual dexterity declined significantly with increasing age. Independent of gender, age, and global cognitive function, increasing magnetic susceptibility in the globus pallidus and red nuclei was associated with decreasing manual dexterity. This finding suggests the potential value of magnetic susceptibility, a non-invasive quantitative imaging marker of iron, for the study of iron-related brain function changes.
dc.language eng
dc.relation.ispartof Neuroimage
dc.relation.isversionof 10.1016/j.neuroimage.2014.10.009
dc.subject Aging
dc.subject Brain iron
dc.subject Cognitive function
dc.subject Magnetic susceptibility
dc.subject Motor control
dc.subject Adult
dc.subject Aged
dc.subject Aged, 80 and over
dc.subject Brain Chemistry
dc.subject Executive Function
dc.subject Female
dc.subject Gray Matter
dc.subject Humans
dc.subject Image Processing, Computer-Assisted
dc.subject Iron
dc.subject Magnetic Phenomena
dc.subject Magnetic Resonance Imaging
dc.subject Male
dc.subject Middle Aged
dc.subject Motor Activity
dc.title Association between increased magnetic susceptibility of deep gray matter nuclei and decreased motor function in healthy adults.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/25315786
pubs.begin-page 45
pubs.end-page 52
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Center for Cognitive Neuroscience
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Duke-UNC Center for Brain Imaging and Analysis
pubs.organisational-group Faculty
pubs.organisational-group Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Neurobiology
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group Psychiatry & Behavioral Sciences
pubs.organisational-group Psychiatry & Behavioral Sciences, Brain Stimulation and Neurophysiology
pubs.organisational-group Psychiatry & Behavioral Sciences, Geriatric Behavioral Health
pubs.organisational-group Psychology and Neuroscience
pubs.organisational-group Radiology
pubs.organisational-group School of Medicine
pubs.organisational-group Temp group - logins allowed
pubs.organisational-group Trinity College of Arts & Sciences
pubs.organisational-group University Institutes and Centers
pubs.publication-status Published
pubs.volume 105
dc.identifier.eissn 1095-9572


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