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Long-term outcomes and management of the heart transplant recipient.

dc.contributor.author Del Rio, JM
dc.contributor.author McCartney, Sharon Lorraine
dc.contributor.author Patel, C
dc.coverage.spatial Netherlands
dc.date.accessioned 2018-01-10T16:33:24Z
dc.date.available 2018-01-10T16:33:24Z
dc.date.issued 2017-06
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/29110796
dc.identifier S1521-6896(17)30039-3
dc.identifier.uri http://hdl.handle.net/10161/15974
dc.description.abstract Cardiac transplantation remains the gold standard in the treatment of advanced heart failure. With advances in immunosuppression, long-term outcomes continue to improve despite older and higher risk recipients. The median survival of the adult after heart transplantation is currently 10.7 years. While early graft failure and multiorgan system dysfunction are the most important causes of early mortality, malignancy, rejection, infection, and cardiac allograft vasculopathy contribute to late mortality. Chronic renal dysfunction is common after heart transplantation and occurs in up to 68% of patients by year 10, with 6.2% of patients requiring dialysis and 3.7% undergoing renal transplant. Functional outcomes after heart transplantation remain an area for improvement, with only 26% of patients working at 1-year post-transplantation, and are likely related to the high incidence of depression after cardiac transplantation. Areas of future research include understanding and managing primary graft dysfunction and reducing immunosuppression-related complications.
dc.language eng
dc.relation.ispartof Best Pract Res Clin Anaesthesiol
dc.relation.isversionof 10.1016/j.bpa.2017.06.003
dc.subject complications
dc.subject graft rejection
dc.subject heart transplantation
dc.subject immunosuppression
dc.subject outcomes
dc.subject transplantation
dc.subject transplants
dc.title Long-term outcomes and management of the heart transplant recipient.
dc.type Journal article
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/29110796
pubs.begin-page 237
pubs.end-page 248
pubs.issue 2
pubs.organisational-group Anesthesiology
pubs.organisational-group Anesthesiology, Cardiothoracic
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Medicine
pubs.organisational-group Medicine, Cardiology
pubs.organisational-group School of Medicine
pubs.organisational-group Temp group - logins allowed
pubs.publication-status Published
pubs.volume 31
dc.identifier.eissn 1878-1608


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