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Seven unconfirmed ideas to improve future ICU practice.

dc.contributor.author Marini, John J
dc.contributor.author De Backer, Daniel
dc.contributor.author Ince, Can
dc.contributor.author Singer, Mervyn
dc.contributor.author Van Haren, Frank
dc.contributor.author Westphal, Martin
dc.contributor.author Wischmeyer, Paul
dc.coverage.spatial England
dc.date.accessioned 2018-01-17T18:21:47Z
dc.date.available 2018-01-17T18:21:47Z
dc.date.issued 2017-12-28
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/29297400
dc.identifier 10.1186/s13054-017-1904-x
dc.identifier.uri https://hdl.handle.net/10161/15998
dc.description.abstract With imprecise definitions, inexact measurement tools, and flawed study execution, our clinical science often lags behind bedside experience and simply documents what appear to be the apparent faults or validity of ongoing practices. These impressions are later confirmed, modified, or overturned by the results of the next trial. On the other hand, insights that stem from the intuitions of experienced clinicians, scientists and educators-while often neglected-help place current thinking into proper perspective and occasionally point the way toward formulating novel hypotheses that direct future research. Both streams of information and opinion contribute to progress. In this paper we present a wide-ranging set of unproven 'out of the mainstream' ideas of our FCCM faculty, each with a defensible rationale and holding clear implications for altering bedside management. Each proposition was designed deliberately to be provocative so as to raise awareness, stimulate new thinking and initiate lively dialog.
dc.language eng
dc.publisher Springer Science and Business Media LLC
dc.relation.ispartof Crit Care
dc.relation.isversionof 10.1186/s13054-017-1904-x
dc.subject Adaptive clinical trials
dc.subject Melatonin
dc.subject Metabolic monitoring
dc.subject Microcirculation
dc.subject Personalized medicine
dc.subject Resuscitation
dc.subject Sepsis
dc.subject Shock
dc.subject Ventilator-induced lung injury
dc.title Seven unconfirmed ideas to improve future ICU practice.
dc.type Journal article
duke.contributor.id Wischmeyer, Paul|0721619
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/29297400
pubs.begin-page 315
pubs.issue Suppl 3
pubs.organisational-group Anesthesiology
pubs.organisational-group Anesthesiology, Critical Care Medicine
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Clinical Research Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group School of Medicine
pubs.publication-status Published online
pubs.volume 21
dc.identifier.eissn 1466-609X


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