A practical method of I-131 thyroid cancer therapy dose optimization using estimated effective renal clearance.
Abstract
In thyroid cancer patients with renal impairment or other complicating factors, it
is important to maximize I-131 therapy efficacy while minimizing bone marrow and lung
damage. We developed a web-based calculator based on a modified Benua and Leeper method
to calculate the maximum I-131 dose to reduce the risk of these toxicities, based
on the effective renal clearance of I-123 as measured from two whole-body I-123 scans,
performed at 0 and 24 h post-administration.
Type
Journal articlePermalink
https://hdl.handle.net/10161/16135Published Version (Please cite this version)
10.1177/2050313X17745203Publication Info
Howard, Brandon A; James, Olga G; Perkins, Jennifer M; Pagnanelli, Robert A; Borges-Neto,
Salvador; & Reiman, Robert E (2017). A practical method of I-131 thyroid cancer therapy dose optimization using estimated
effective renal clearance. SAGE Open Med Case Rep, 5. 10.1177/2050313X17745203. Retrieved from https://hdl.handle.net/10161/16135.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Salvador Borges-Neto
Professor of Radiology
Expertise:
1. Diagnostic and Prognostic Utility of Cardiovascular Nuclear Medicine in Heart
Disease. 2. The Role of Cardiac PET/CT in Cardiac Sarcoidosis and Ischemic Heart
Disease. 3. The Role of Nuclear Cardiology in Diagnosis and Management of Amyloidosis.
4. Left Ventricular Dyssynchrony Evaluation by GSPECT.
I am a Professor of Radiology (Nuclear Medicine) and Internal Medicine at Duke University
Medical Center. I also serve as
Brandon Augustus Howard
Assistant Professor of Radiology
Robert Ellis Reiman Jr.
Associate Professor of Radiology
Dr. Reiman is diplomate of the American Board of Nuclear Medicine, and is the Associate
Director the Radiation Safety Division of Duke's Occupational and Environmental Safety
Office. He is on the faculty the Department of Radiology and is a member of the Faculty
of the Duke Medical Physics Graduate Program. He coordinates the patient care activities
of the Duke Radiation Safety Division and participates in the teaching of radiology
residents, nuclear medicine fellows,
Alphabetical list of authors with Scholars@Duke profiles.

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