Cytokine biomarkers in tear film for primary open-angle glaucoma.
Abstract
PURPOSE: To determine the utility of tear film cytokines as biomarkers for early primary
open-angle glaucoma (POAG). METHODS: Patients without POAG and eye drop-naïve patients
with newly diagnosed POAG were recruited from an academic hospital-based glaucoma
practice. Tear films of recruited patients were obtained and analyzed using a multiplex,
high-sensitivity electrochemiluminescent enzyme-linked immunosorbent assay for proinflammatory
cytokines (IFNγ, IL-10, IL-12p70, IL-13, IL-1β, IL-2, IL-4, IL-6, IL-8, and TNFα).
RESULTS: Mean concentrations of tear film cytokines were lower in the glaucoma group
for 8 of 10 cytokines tested. IL-12p70 (3.94±2.19 pg/mL in control vs 2.31±1.156 pg/mL
in POAG;P=0.035) was significantly lower in the tear film of patients with newly diagnosed
POAG. CONCLUSION: Proinflammatory cytokines were lower in eye drop-naïve newly diagnosed
glaucoma patients. Tear film cytokine profiles may be used as biomarkers of early
POAG.
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https://hdl.handle.net/10161/16164Published Version (Please cite this version)
10.2147/OPTH.S125364Publication Info
(2017). Cytokine biomarkers in tear film for primary open-angle glaucoma. Clin Ophthalmol, 11. pp. 411-416. 10.2147/OPTH.S125364. Retrieved from https://hdl.handle.net/10161/16164.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Divakar Gupta
Associate Professor of Ophthalmology
Divakar Gupta, MD is a board certified, fellowship-trained ophthalmologist specializing
in the medical and surgical treatment of glaucoma and cataracts. He performs both
traditional glaucoma surgery such as trabeculectomy and glaucoma tube shunts, as well
as cutting-edge Minimally Invasive Glaucoma Surgery (MIGS). He is trained in the
latest surgical techniques of cataract and laser-assisted cataract surgery. Dr. Gupta
also offers premium intraocular lenses
Virginia Byers Kraus
Mary Bernheim Distinguished Professor of Medicine
My special area of expertise is as a clinician scientist investigating osteoarthritis.
Osteoarthritis is the most common form of joint disease in man and its incidence increases
with age. It is a problem of increasing concern to the medical community due to the
increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist,
I endeavor to study this disease from bedside to bench. The work in this laboratory
focuses on osteoarthritis and deals w
Sandra Sue Stinnett
Associate Professor of Biostatistics & Bioinformatics
Analysis of data for ophthalmology including observational studies and clinical trials.
Assessment of reproducibility in grading measurements for ophthalmic studies. Teaching
medical statistics.
Molly McCarthy Walsh
Assistant Professor of Ophthalmology
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