Cytokine biomarkers in tear film for primary open-angle glaucoma.
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PURPOSE: To determine the utility of tear film cytokines as biomarkers for early primary open-angle glaucoma (POAG). METHODS: Patients without POAG and eye drop-naïve patients with newly diagnosed POAG were recruited from an academic hospital-based glaucoma practice. Tear films of recruited patients were obtained and analyzed using a multiplex, high-sensitivity electrochemiluminescent enzyme-linked immunosorbent assay for proinflammatory cytokines (IFNγ, IL-10, IL-12p70, IL-13, IL-1β, IL-2, IL-4, IL-6, IL-8, and TNFα). RESULTS: Mean concentrations of tear film cytokines were lower in the glaucoma group for 8 of 10 cytokines tested. IL-12p70 (3.94±2.19 pg/mL in control vs 2.31±1.156 pg/mL in POAG;P=0.035) was significantly lower in the tear film of patients with newly diagnosed POAG. CONCLUSION: Proinflammatory cytokines were lower in eye drop-naïve newly diagnosed glaucoma patients. Tear film cytokine profiles may be used as biomarkers of early POAG.
Published Version (Please cite this version)10.2147/OPTH.S125364
Publication InfoGupta, Divakar; Wen, Joanne C; Huebner, Janet L; Stinnett, Sandra; Kraus, Virginia B; Tseng, Henry C; & Walsh, Molly (2017). Cytokine biomarkers in tear film for primary open-angle glaucoma. Clin Ophthalmol, 11. pp. 411-416. 10.2147/OPTH.S125364. Retrieved from https://hdl.handle.net/10161/16164.
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Associate Professor of Ophthalmology
Divakar Gupta, MD is a board certified, fellowship-trained ophthalmologist specializing in the medical and surgical treatment of glaucoma and cataracts. He performs both traditional glaucoma surgery such as trabeculectomy and glaucoma tube shunts, as well as cutting-edge Minimally Invasive Glaucoma Surgery (MIGS). He is trained in the latest surgical techniques of cataract and laser-assisted cataract surgery. Dr. Gupta also offers premium intraocular lenses
Virginia Byers Kraus
Mary Bernheim Distinguished Professor of Medicine
My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench. The work in this laboratory focuses on osteoarthritis and deals w
Sandra Sue Stinnett
Associate Professor of Biostatistics & Bioinformatics
Analysis of data for ophthalmology including observational studies and clinical trials. Assessment of reproducibility in grading measurements for ophthalmic studies. Teaching medical statistics.
Molly McCarthy Walsh
Assistant Professor of Ophthalmology
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