Optic Disc Perfusion in Primary Open Angle and Normal Tension Glaucoma Eyes Using Optical Coherence Tomography-Based Microangiography.
Abstract
PURPOSE: To investigate optic disc perfusion differences in normal, primary open-angle
glaucoma (POAG), and normal tension glaucoma (NTG) eyes using optical microangiography
(OMAG) based optical coherence tomography (OCT) angiography technique. DESIGN: Cross-sectional,
observational study. SUBJECTS: Twenty-eight normal, 30 POAG, and 31 NTG subjects.
METHODS: One eye from each subject was scanned with a 68 kHz Cirrus HD-OCT 5,000-based
OMAG prototype system centered at the optic nerve head (ONH) (Carl Zeiss Meditec Inc,
Dublin, CA). Microvascular images were generated from the OMAG dataset by detecting
the differences in OCT signal between consecutive B-scans. The pre-laminar layer (preLC)
was isolated by a semi-automatic segmentation program. MAIN OUTCOME MEASURES: Optic
disc perfusion, quantified as flux, vessel area density, and normalized flux (flux
normalized by the vessel area) within the ONH. RESULTS: Glaucomatous eyes had significantly
lower optic disc perfusion in preLC in all three perfusion metrics (p<0.0001) compared
to normal eyes. The visual field (VF) mean deviation (MD) and pattern standard deviation
(PSD) were similar between the POAG and NTG groups, and no differences in optic disc
perfusion were observed between POAG and NTG. Univariate analysis revealed significant
correlation between optic disc perfusion and VF MD, VF PSD, and rim area in both POAG
and NTG groups (p≤0.0288). However, normalized optic disc perfusion was correlated
with some structural measures (retinal nerve fiber layer thickness and ONH cup/disc
ratio) only in POAG eyes. CONCLUSIONS: Optic disc perfusion detected with OMAG was
significantly reduced in POAG and NTG groups compared to normal controls, but no difference
was seen between POAG and NTG groups with similar levels of VF damage. Disc perfusion
was significantly correlated with VF MD, VF PSD, and rim area in glaucomatous eyes.
Vascular changes at the optic disc as measured using OMAG may provide useful information
for diagnosis and monitoring of glaucoma.
Type
Journal articleSubject
AngiographyCase-Control Studies
Glaucoma, Open-Angle
Humans
Low Tension Glaucoma
Optic Disk
Tomography, Optical Coherence
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https://hdl.handle.net/10161/16165Published Version (Please cite this version)
10.1371/journal.pone.0154691Publication Info
Bojikian, Karine D; Chen, Chieh-Li; Wen, Joanne C; Zhang, Qinqin; Xin, Chen; Gupta,
Divakar; ... Chen, Philip P (2016). Optic Disc Perfusion in Primary Open Angle and Normal Tension Glaucoma Eyes Using
Optical Coherence Tomography-Based Microangiography. PLoS One, 11(5). pp. e0154691. 10.1371/journal.pone.0154691. Retrieved from https://hdl.handle.net/10161/16165.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Divakar Gupta
Associate Professor of Ophthalmology
Divakar Gupta, MD is a board certified, fellowship-trained ophthalmologist specializing
in the medical and surgical treatment of glaucoma and cataracts. He performs both
traditional glaucoma surgery such as trabeculectomy and glaucoma tube shunts, as well
as cutting-edge Minimally Invasive Glaucoma Surgery (MIGS). He is trained in the
latest surgical techniques of cataract and laser-assisted cataract surgery. Dr. Gupta
also offers premium intraocular lenses

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