Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent.
Abstract
A long circulating liposomal, nanoscale blood pool agent encapsulating traditional
iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT)
imaging of rats implanted with R3230AC mammary carcinoma. Three-dimensional vascular
architecture of tumors was imaged at 100-micron isotropic resolution. The image data
showed good qualitative correlation with pathologic findings. The approach holds promise
for studying tumor angiogenesis and for evaluating anti-angiogenesis therapies.
Type
Journal articleSubject
angiogenesisbreast cancer
liposome
micro-CT
molecular imaging
small animal imaging
Animals
Cell Line, Tumor
Contrast Media
Female
Iopamidol
Liposomes
Mammary Neoplasms, Animal
Mammography
Nanoparticles
Radiographic Image Enhancement
Rats
Rats, Inbred F344
Tomography, X-Ray Computed
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Show full item recordScholars@Duke
Cristian Tudorel Badea
Professor in Radiology
Our lab's research focus lies primarily in developing novel quantitative imaging systems,
reconstruction algorithms and analysis methods. My major expertise is in preclinical
CT.
Currently, we are particularly interested in developing novel strategies for spectral
CT imaging using nanoparticle-based contrast agents for theranostics (i.e. therapy
and diagnostics).
We are also engaged in developin
Rex Colle Bentley
Professor of Pathology
Outcome-based research on pathology of endometrial carcinoma, including prognostic
significance of histologic features of endometrial carcinoma, variants of endometrial
carcinoma, definitions of atypia and well-differentiated carcinoma, and collaborative
studies of oncogenes and tumor suppressor genes in endometrial carcinoma. Endometrial
pathology, especially as it relates to molecular/genetic alterations in neoplasms.
Ovarian pathology, especially as it relates to mol
Laurence William Hedlund
Professor Emeritus of Radiology
Currently, major effort is devoted to developing and utilizing magnetic resonance
(MR) microscopy for in vivo histologic studies of major organs systems in small animals
such as rats and guinea pigs. This work takes two directions: 1. development of
monitoring and physiologic and support systems and 2. examination of magnetic resonance
correlates of the microscopic changes that occur in the lungs, liver, kidneys, brain
and blood vessels. MR imaging at microscopic resolution in live s
This author no longer has a Scholars@Duke profile, so the information shown here reflects
their Duke status at the time this item was deposited.
Ehsan Samei
Reed and Martha Rice Distinguished Professor of Radiology
Dr. Ehsan Samei, PhD, DABR, FAAPM, FSPIE, FAIMBE, FIOMP, FACR is a Persian-American
medical physicist. He is a tenured Professor of Radiology, Medical Physics, Biomedical
Engineering, Physics, and Electrical and Computer Engineering at Duke University,
where he also serves as the Chief Imaging Physicist for Duke University Health System,
the director of the Carl E Ravin Advanced Imaging Laboratories, and the director of
Center for Virtual Imaging Trials. He is certi
Robert Saunders
Adjunct Associate Professor in the Duke-Margolis Center for Health Policy
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