Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent.
Repository Usage Stats
A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. Three-dimensional vascular architecture of tumors was imaged at 100-micron isotropic resolution. The image data showed good qualitative correlation with pathologic findings. The approach holds promise for studying tumor angiogenesis and for evaluating anti-angiogenesis therapies.
small animal imaging
Cell Line, Tumor
Mammary Neoplasms, Animal
Radiographic Image Enhancement
Rats, Inbred F344
Tomography, X-Ray Computed
More InfoShow full item record
Professor Emeritus of Radiology
Currently, major effort is devoted to developing and utilizing magnetic resonance (MR) microscopy for in vivo histologic studies of major organs systems in small animals such as rats and guinea pigs. This work takes two directions: 1. development of monitoring and physiologic and support systems and 2. examination of magnetic resonance correlates of the microscopic changes that occur in the lungs, liver, kidneys, brain and blood vessels. MR imaging at microscopic resolution in live s
Professor of Radiology
Dr. Ehsan Samei, PhD, DABR, FAAPM, FSPIE, FAIMBE is a Persian-American medical physicist. He is a tenured Professor of Radiology, Medical Physics, Biomedical Engineering, Physics, and Electrical and Computer Engineering at Duke University. He serves as the Director of the Duke Medical Physics Graduate Program and the Director of the Clinical Imaging Physics Group. He is certified by the American Board of Radiology, and is a Fellow o
Alphabetical list of authors with Scholars@Duke profiles.