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Fungal infections in HIV/AIDS.

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Date
2017-11
Authors
Limper, Andrew H
Adenis, Antoine
Le, Thuy
Harrison, Thomas S
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Abstract
Fungi are major contributors to the opportunistic infections that affect patients with HIV/AIDS. Systemic infections are mainly with Pneumocystis jirovecii (pneumocystosis), Cryptococcus neoformans (cryptococcosis), Histoplasma capsulatum (histoplasmosis), and Talaromyces (Penicillium) marneffei (talaromycosis). The incidence of systemic fungal infections has decreased in people with HIV in high-income countries because of the widespread availability of antiretroviral drugs and early testing for HIV. However, in many areas with high HIV prevalence, patients present to care with advanced HIV infection and with a low CD4 cell count or re-present with persistent low CD4 cell counts because of poor adherence, resistance to antiretroviral drugs, or both. Affordable, rapid point-of-care diagnostic tests (as have been developed for cryptococcosis) are urgently needed for pneumocystosis, talaromycosis, and histoplasmosis. Additionally, antifungal drugs, including amphotericin B, liposomal amphotericin B, and flucytosine, need to be much more widely available. Such measures, together with continued international efforts in education and training in the management of fungal disease, have the potential to improve patient outcomes substantially.
Type
Journal article
Subject
AIDS-Related Opportunistic Infections
Antifungal Agents
Diagnostic Tests, Routine
Fungi
HIV Infections
Humans
Incidence
Mycoses
Point-of-Care Systems
Permalink
https://hdl.handle.net/10161/16183
Published Version (Please cite this version)
10.1016/S1473-3099(17)30303-1
Publication Info
Limper, Andrew H; Adenis, Antoine; Le, Thuy; & Harrison, Thomas S (2017). Fungal infections in HIV/AIDS. Lancet Infect Dis, 17(11). pp. e334-e343. 10.1016/S1473-3099(17)30303-1. Retrieved from https://hdl.handle.net/10161/16183.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Le

Thuy Le

Associate Professor of Medicine
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