Show simple item record

Behavioural and physiological limits to vision in mammals.

dc.contributor.author Field, Greg
dc.contributor.author Sampath, Alapakkam P
dc.date.accessioned 2018-05-01T13:35:42Z
dc.date.available 2018-05-01T13:35:42Z
dc.date.issued 2017-04
dc.identifier.issn 0962-8436
dc.identifier.issn 1471-2970
dc.identifier.uri https://hdl.handle.net/10161/16627
dc.description.abstract Human vision is exquisitely sensitive-a dark-adapted observer is capable of reliably detecting the absorption of a few quanta of light. Such sensitivity requires that the sensory receptors of the retina, rod photoreceptors, generate a reliable signal when single photons are absorbed. In addition, the retina must be able to extract this information and relay it to higher visual centres under conditions where very few rods signal single-photon responses while the majority generate only noise. Critical to signal transmission are mechanistic optimizations within rods and their dedicated retinal circuits that enhance the discriminability of single-photon responses by mitigating photoreceptor and synaptic noise. We describe behavioural experiments over the past century that have led to the appreciation of high sensitivity near absolute visual threshold. We further consider mechanisms within rod photoreceptors and dedicated rod circuits that act to extract single-photon responses from cellular noise. We highlight how these studies have shaped our understanding of brain function and point out several unresolved questions in the processing of light near the visual threshold.This article is part of the themed issue 'Vision in dim light'.
dc.language eng
dc.relation.ispartof Philosophical transactions of the Royal Society of London. Series B, Biological sciences
dc.relation.isversionof 10.1098/rstb.2016.0072
dc.subject Animals
dc.subject Mammals
dc.subject Sensory Thresholds
dc.subject Visual Perception
dc.subject Vision, Ocular
dc.title Behavioural and physiological limits to vision in mammals.
dc.type Journal article
dc.date.updated 2018-05-01T13:35:40Z
pubs.issue 1717
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Biomedical Engineering
pubs.organisational-group Pratt School of Engineering
pubs.organisational-group Neurobiology
pubs.organisational-group Basic Science Departments
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group University Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.publication-status Published
pubs.volume 372


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record