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A Connectome Wide Functional Signature of Transdiagnostic Risk for Mental Illness
Abstract
Background High rates of comorbidity, shared risk, and overlapping therapeutic mechanisms
have led psychopathology research towards transdiagnostic dimensional investigations
of clustered symptoms. One influential framework accounts for these transdiagnostic
phenomena through a single general factor, sometimes referred to as the ‘p’ factor,
associated with risk for all common forms of mental illness. Methods Here we build
on past research identifying unique structural neural correlates of the p factor by
conducting a data-driven analysis of connectome wide intrinsic functional connectivity
(n = 605). Results We demonstrate that higher p factor scores and associated risk
for common mental illness maps onto hyper-connectivity between visual association
cortex and both frontoparietal and default mode networks. Conclusions These results
provide initial evidence that the transdiagnostic risk for common forms of mental
illness is associated with patterns of inefficient connectome wide intrinsic connectivity
between visual association cortex and networks supporting executive control and self-referential
processes, networks which are often impaired across categorical disorders.
Type
Journal articlePermalink
https://hdl.handle.net/10161/16709Published Version (Please cite this version)
10.1016/j.biopsych.2018.03.012Publication Info
Elliott, ML; Romer, A; Knodt, AR; & Hariri, AR (2018). A Connectome Wide Functional Signature of Transdiagnostic Risk for Mental Illness.
Biological Psychiatry. 10.1016/j.biopsych.2018.03.012. Retrieved from https://hdl.handle.net/10161/16709.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Maxwell Elliott
Teaching Assistant
Max is a clinical psychology PhD student working with Ahmad Hariri and the Moffitt
& Caspi lab after completing his BS at the University of Minnesota and spending two
years as a research fellow at the National Institute of Mental Health. Max is interested
in further understanding the structure of mental illness through investigating the
interacting relationships between genes, environment and the brain. He is particularly
interested in finding ways to combine knowledge ab
Ahmad Hariri
Professor of Psychology and Neuroscience
Integrating psychology, neuroimaging, pharmacology and molecular genetics in the search
for biological pathways mediating individual differences in behavior and related risk
for psychopathology.
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