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Genome-wide Metabolic Reconstruction and Flux Balance Analysis Modeling of Haloferax volcanii

dc.contributor.advisor Reddy, Timothy
dc.contributor.author Rosko, Andrew S
dc.date.accessioned 2018-05-31T21:19:18Z
dc.date.available 2018-05-31T21:19:18Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/10161/17074
dc.description.abstract <p>The Archaea are an understudied domain of the tree of life, and consist of single-celled microorganisms possessing rich metabolic diversity. Archaeal metabolic capabilities are of interest for industry and basic understanding of the early evolution of metabolism. However, archaea possess many unusual pathways that remain unknown or unclear. To address this knowledge gap, here I built a whole-genome metabolic reconstruction of a model archaeal species, Haloferax volcanii, which included several atypical reactions and pathways in this organism. I then use flux balance analysis to predict fluxes through central carbon metabolism during growth on minimal media containing two different sugars. This establishes a foundation for the future study of the regulation of metabolism in H. volcanii and evolutionary comparison with other archaea.</p>
dc.subject Biology
dc.subject Biochemistry
dc.subject Bioengineering
dc.subject Archaea
dc.subject Flux balance analysis
dc.subject Metabolic modeling
dc.title Genome-wide Metabolic Reconstruction and Flux Balance Analysis Modeling of Haloferax volcanii
dc.type Master's thesis
dc.department Computational Biology and Bioinformatics


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