Tissue-Integrating Oxygen Sensors: Continuous Tracking of Tissue Hypoxia.
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We describe a simple method of tracking oxygen in real-time with injectable, tissue-integrating microsensors. The sensors are small (500 μm × 500 μm × 5 mm), soft, flexible, tissue-like, biocompatible hydrogel s that have been shown to overcome the foreign body response for long-term sensing. The sensors are engineered to change luminescence in the presence of oxygen or other analytes and function for months to years in the body. A single injection followed by non-invasive monitoring with a hand-held or wearable Bluetooth optical reader enables intermittent or continuous measurements. Proof of concept for applications in high altitude, exercise physiology, vascular disease, stroke, tumors, and other disease states have been shown in mouse, rat and porcine models. Over 90 sensors have been studied to date in humans. These novel tissue-integrating sensors yield real-time insights in tissue oxygen fluctuations for research and clinical applications.
Published Version (Please cite this version)10.1007/978-3-319-55231-6_49
Publication InfoKlitzman, Bruce; Wisniewski, Natalie A; Nichols, Scott P; Gamsey, Soya J; Pullins, Steve; Au-Yeung, Kit Y; & Helton, Kristen L (2017). Tissue-Integrating Oxygen Sensors: Continuous Tracking of Tissue Hypoxia. Advances in experimental medicine and biology, 977. 10.1007/978-3-319-55231-6_49. Retrieved from https://hdl.handle.net/10161/17081.
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Associate Professor of Surgery
Our overriding interests are in the fields of tissue engineering, wound healing, biosensors, and long term improvement of medical device implantation. My basic research interests are in the area of physiological mechanisms of optimizing substrate transport to tissue. This broad topic covers studies on a whole animal, whole organ, hemorheological, microvascular, cellular, ultrastructural, and molecular level. The current projects include: 1) control of blood flow and flow distribu