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The Emerging Role of Inflammasomes as Central Mediators in Inflammatory Bladder Pathology.

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Date
2018-02
Authors
Inouye, Brian M
Hughes, Francis M
Sexton, Stephanie J
Purves, J Todd
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Abstract
Irritative voiding symptoms (e.g. increased frequency and urgency) occur in many common pathologic conditions such as urinary tract infections and bladder outlet obstruction, and these conditions are well-established to have underlying inflammation that directly triggers these symptoms. However, it remains unclear as to how such diverse stimuli individually generate a common inflammatory process. Jürg Tschopp provided substantial insight into this conundrum when, working with extracts from THP-1 cells, he reported the existence of the inflammasome. He described it as a structure that senses multiple diverse signals from intracellular/extracellular sources and pathogens and triggers inflammation by the maturation and release of the pro-inflammatory cytokines interleukin-1β and interleukin-18. Recently, many of these sensors were found in the bladder and the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3, has been shown to be a central mediator of inflammation in several urological diseases. In this review, we introduce the nucleotide-binding domain, leucine-rich-containing family, pyrin domaincontaining-3 inflammasome, highlight its emerging role in several common urologic conditions, and speculate on the potential involvement of other inflammasomes in bladder pathology.
Type
Journal article
Subject
Bladder cancer
Bladder outlet obstruction
Inflammasomes
NLRP3
Urinary tract infection
Urothelial carcinoma
Permalink
https://hdl.handle.net/10161/17171
Published Version (Please cite this version)
10.1159/000447196
Publication Info
Inouye, Brian M; Hughes, Francis M; Sexton, Stephanie J; & Purves, J Todd (2018). The Emerging Role of Inflammasomes as Central Mediators in Inflammatory Bladder Pathology. Current urology, 11(2). pp. 57-72. 10.1159/000447196. Retrieved from https://hdl.handle.net/10161/17171.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Hughes

Monty Hughes Jr.

Assistant Professor in Surgery
 Dr. Hughes received his Ph.D. from the Medical University of South Carolina and was a post doc at both the University of North Carolina at Chapel Hill and NIH. He then joined the faculty of the University of North Carolina at Charlotte where he rose to the rank of Associate Professor (with tenure). Following a brief stint as the director of the biology division of a start-up pharmaceutical company, he joined forces with Dr. Purves at the Medical University of South Carolina to begin this l
Inouye

Brian Masao Inouye

Clinical Associate in the Department of Surgery
This author no longer has a Scholars@Duke profile, so the information shown here reflects their Duke status at the time this item was deposited.
Purves

J Todd Purves

Associate Professor of Surgery
Alphabetical list of authors with Scholars@Duke profiles.
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