The Emerging Role of Inflammasomes as Central Mediators in Inflammatory Bladder Pathology.
Abstract
Irritative voiding symptoms (e.g. increased frequency and urgency) occur in many common
pathologic conditions such as urinary tract infections and bladder outlet obstruction,
and these conditions are well-established to have underlying inflammation that directly
triggers these symptoms. However, it remains unclear as to how such diverse stimuli
individually generate a common inflammatory process. Jürg Tschopp provided substantial
insight into this conundrum when, working with extracts from THP-1 cells, he reported
the existence of the inflammasome. He described it as a structure that senses multiple
diverse signals from intracellular/extracellular sources and pathogens and triggers
inflammation by the maturation and release of the pro-inflammatory cytokines interleukin-1β
and interleukin-18. Recently, many of these sensors were found in the bladder and
the nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3,
has been shown to be a central mediator of inflammation in several urological diseases.
In this review, we introduce the nucleotide-binding domain, leucine-rich-containing
family, pyrin domaincontaining-3 inflammasome, highlight its emerging role in several
common urologic conditions, and speculate on the potential involvement of other inflammasomes
in bladder pathology.
Type
Journal articleSubject
Bladder cancerBladder outlet obstruction
Inflammasomes
NLRP3
Urinary tract infection
Urothelial carcinoma
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https://hdl.handle.net/10161/17171Published Version (Please cite this version)
10.1159/000447196Publication Info
Inouye, Brian M; Hughes, Francis M; Sexton, Stephanie J; & Purves, J Todd (2018). The Emerging Role of Inflammasomes as Central Mediators in Inflammatory Bladder Pathology.
Current urology, 11(2). pp. 57-72. 10.1159/000447196. Retrieved from https://hdl.handle.net/10161/17171.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Monty Hughes Jr.
Assistant Professor in Surgery
Dr. Hughes received his Ph.D. from the Medical University of South Carolina and was
a post doc at both the University of North Carolina at Chapel Hill and NIH. He then
joined the faculty of the University of North Carolina at Charlotte where he rose
to the rank of Associate Professor (with tenure). Following a brief stint as the director
of the biology division of a start-up pharmaceutical company, he joined forces with
Dr. Purves at the Medical University of South Carolina to begin this l
Brian Masao Inouye
Clinical Associate in the Department of Surgery
This author no longer has a Scholars@Duke profile, so the information shown here reflects
their Duke status at the time this item was deposited.
J Todd Purves
Associate Professor of Surgery
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