Inflammasomes in the urinary tract: a disease-based review.
Abstract
Inflammasomes are supramolecular structures that sense molecular patterns from pathogenic
organisms or damaged cells and trigger an innate immune response, most commonly through
production of the proinflammatory cytokines IL-1β and IL-18, but also through less
understood mechanisms independent of these cytokines. Great strides have been made
in understanding these structures and their dysfunction in various inflammatory diseases,
lending new insights into urological and renal problems. From a clinical perspective,
benign urinary pathology almost universally involves the inflammatory process, and
understanding how inflammasomes translate etiological conditions (diabetes, obstruction,
stones, urinary tract infections, etc.) into acute and chronic inflammatory responses
is critical to understanding these diseases at a molecular level. To date, inflammasome
components have been found in the bladder, prostate, and kidney and have been shown
to be activated in response to several infectious and noninfectious insults. In this
review, we summarize what is known regarding inflammasomes in both the upper and lower
urinary tract and describe several common disease states where they potentially play
critical roles.
Type
Journal articleSubject
Urinary TractKidney
Animals
Humans
Cystitis
Urinary Bladder
Urinary Bladder Neck Obstruction
Immunity, Innate
Inflammasomes
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https://hdl.handle.net/10161/17175Published Version (Please cite this version)
10.1152/ajprenal.00607.2015Publication Info
Purves, J Todd; & Hughes, F Monty (2016). Inflammasomes in the urinary tract: a disease-based review. American journal of physiology. Renal physiology, 311(4). pp. F653-F662. 10.1152/ajprenal.00607.2015. Retrieved from https://hdl.handle.net/10161/17175.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Monty Hughes Jr.
Assistant Professor in Urology
Dr. Hughes received his Ph.D. from the Medical University of South Carolina and was
a post doc at both the University of North Carolina at Chapel Hill and NIH. He then
joined the faculty of the University of North Carolina at Charlotte where he rose
to the rank of Associate Professor (with tenure). Following a brief stint as the director
of the biology division of a start-up pharmaceutical company, he joined forces with
Dr. Purves at the Medical University of South Carolina to begin this l
J Todd Purves
Professor of Urology
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