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Inflammasomes in the urinary tract: a disease-based review.

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Date
2016-10
Authors
Purves, J Todd
Hughes, F Monty
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Abstract
Inflammasomes are supramolecular structures that sense molecular patterns from pathogenic organisms or damaged cells and trigger an innate immune response, most commonly through production of the proinflammatory cytokines IL-1β and IL-18, but also through less understood mechanisms independent of these cytokines. Great strides have been made in understanding these structures and their dysfunction in various inflammatory diseases, lending new insights into urological and renal problems. From a clinical perspective, benign urinary pathology almost universally involves the inflammatory process, and understanding how inflammasomes translate etiological conditions (diabetes, obstruction, stones, urinary tract infections, etc.) into acute and chronic inflammatory responses is critical to understanding these diseases at a molecular level. To date, inflammasome components have been found in the bladder, prostate, and kidney and have been shown to be activated in response to several infectious and noninfectious insults. In this review, we summarize what is known regarding inflammasomes in both the upper and lower urinary tract and describe several common disease states where they potentially play critical roles.
Type
Journal article
Subject
Urinary Tract
Kidney
Animals
Humans
Cystitis
Urinary Bladder
Urinary Bladder Neck Obstruction
Immunity, Innate
Inflammasomes
Permalink
https://hdl.handle.net/10161/17175
Published Version (Please cite this version)
10.1152/ajprenal.00607.2015
Publication Info
Purves, J Todd; & Hughes, F Monty (2016). Inflammasomes in the urinary tract: a disease-based review. American journal of physiology. Renal physiology, 311(4). pp. F653-F662. 10.1152/ajprenal.00607.2015. Retrieved from https://hdl.handle.net/10161/17175.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Hughes

Monty Hughes Jr.

Assistant Professor in Surgery
 Dr. Hughes received his Ph.D. from the Medical University of South Carolina and was a post doc at both the University of North Carolina at Chapel Hill and NIH. He then joined the faculty of the University of North Carolina at Charlotte where he rose to the rank of Associate Professor (with tenure). Following a brief stint as the director of the biology division of a start-up pharmaceutical company, he joined forces with Dr. Purves at the Medical University of South Carolina to begin this l
Purves

J Todd Purves

Associate Professor of Surgery
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