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Inflammasomes in the urinary tract: a disease-based review. Purves, J Todd Hughes, F Monty 2018-06-26T13:42:54Z 2018-06-26T13:42:54Z 2016-10
dc.identifier.issn 1931-857X
dc.identifier.issn 1522-1466
dc.description.abstract Inflammasomes are supramolecular structures that sense molecular patterns from pathogenic organisms or damaged cells and trigger an innate immune response, most commonly through production of the proinflammatory cytokines IL-1β and IL-18, but also through less understood mechanisms independent of these cytokines. Great strides have been made in understanding these structures and their dysfunction in various inflammatory diseases, lending new insights into urological and renal problems. From a clinical perspective, benign urinary pathology almost universally involves the inflammatory process, and understanding how inflammasomes translate etiological conditions (diabetes, obstruction, stones, urinary tract infections, etc.) into acute and chronic inflammatory responses is critical to understanding these diseases at a molecular level. To date, inflammasome components have been found in the bladder, prostate, and kidney and have been shown to be activated in response to several infectious and noninfectious insults. In this review, we summarize what is known regarding inflammasomes in both the upper and lower urinary tract and describe several common disease states where they potentially play critical roles.
dc.language eng
dc.publisher American Physiological Society
dc.relation.ispartof American journal of physiology. Renal physiology
dc.relation.isversionof 10.1152/ajprenal.00607.2015
dc.subject Urinary Tract
dc.subject Kidney
dc.subject Animals
dc.subject Humans
dc.subject Cystitis
dc.subject Urinary Bladder
dc.subject Urinary Bladder Neck Obstruction
dc.subject Immunity, Innate
dc.subject Inflammasomes
dc.title Inflammasomes in the urinary tract: a disease-based review.
dc.type Journal article Purves, J Todd|0685081 Hughes, F Monty|0686657 2018-06-26T13:42:53Z
pubs.begin-page F653
pubs.end-page F662
pubs.issue 4
pubs.organisational-group Staff
pubs.organisational-group Duke
pubs.organisational-group School of Medicine
pubs.organisational-group Surgery, Urology
pubs.organisational-group Surgery
pubs.organisational-group Clinical Science Departments
pubs.publication-status Published
pubs.volume 311
duke.contributor.orcid Purves, J Todd|0000-0001-9689-2047
duke.contributor.orcid Hughes, F Monty|0000-0003-3776-3653

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