Metastatic Renal Cell Carcinoma as Solitary Subcentimeter Polypoid Gastric Mucosal Lesions: Clinicopathologic Analysis of Five Cases.
Abstract
The stomach is an uncommon site for metastatic carcinoma. Approximately 6% of renal
cell carcinomas (RCCs) may metastasize to the stomach. The majority of the reported
metastatic RCCs in the stomach presented as large masses or ulcers greater than a
centimeter in size. It is very rare to encounter metastatic RCC as a solitary small
polypoid gastric mucosal lesion.In this study, we collected surgical pathology cases
of gastric metastasis from RCC that measured 1.0 cm or less at the time of endoscopy.
The clinicopathological characteristics were analyzed.Five patients with subcentimeter
metastatic RCC involving the gastric mucosa were identified. The clinical presentation
for upper endoscopic examination was non-specific. Two of the five patients did not
have a known history of RCC. In the three patients with a previous history of RCC,
the interval from primary RCC diagnosis to the detection of gastric mucosal metastasis
was 5, 6, and 10 years, respectively. Endoscopically, all the lesions were solitary,
ranging in size from 0.4 to 1 cm. Histologically, all five cases were of the clear
cell type consisting of a bland clear cell proliferation within the lamina propria.
Although the tumor cells were relatively bland, the presence of clear cytoplasm, nuclear
membrane irregularity, occasional enlarged hyperchromatic atypical nuclei, and destructive
growth in the center of the lesion should promote immunohistochemical workup. Immunohistochemically,
the RCC cells exhibited at least patchy immunoreactivity for cytokeratin and RCC markers.
In two cases, there were many CD68 positive foamy histiocytes intermingled with the
tumor cells.Metastatic RCC can rarely present as subcentimeter polypoid gastric mucosal
lesions. The remote or unknown history of RCC, the non-specific endoscopic appearance,
and the bland histological features may lead to a potential diagnostic pitfall. It
is of importance to raise the awareness of such an unusual presentation of metastatic
RCC in the stomach and to include metastatic RCC in the differential diagnosis for
gastric mucosal polyps with clear cell morphology.
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https://hdl.handle.net/10161/17212Published Version (Please cite this version)
10.14740/gr952wPublication Info
Hemmerich, Amanda; Shaar, Mohanad; Burbridge, Rebecca; Guy, Cynthia D; McCall, Shannon
J; Cardona, Diana M; ... Zhang, Xuefeng (2018). Metastatic Renal Cell Carcinoma as Solitary Subcentimeter Polypoid Gastric Mucosal
Lesions: Clinicopathologic Analysis of Five Cases. Gastroenterology research, 11(1). pp. 25-30. 10.14740/gr952w. Retrieved from https://hdl.handle.net/10161/17212.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Diana Marcella Cardona
Associate Professor of Pathology
I am active in translational research involving gastrointestinal/hepatobiliary pathology
[specifically transplant related pathology (GVHD and rejection) and carcinogenesis
of the pancreas] and bone and soft tissue malignancies [imaging techniques for intraoperative
margin assessment].
Shannon Jones McCall
Associate Professor of Pathology
As Vice Chair for Translational Research in the Department of Pathology, I am involved
in numerous translational cancer research projects that rely on the study of human
biological samples. I am the director of the Duke BioRepository & Precision Pathology
Center (Duke BRPC), a shared resource of the School of Medicine and the Duke Cancer
Institute. I serve as the PI for the National Cancer Institute's Cooperative Human
Tissue Network Southern Division (a five-year UM1 grant), whi
Xuefeng Zhang
Adjunct Associate Professor in the Department of Pathology
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