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The Risk of Cardiac Device-Related Infection in Bacteremic Patients Is Species Specific: Results of a 12-Year Prospective Cohort.

dc.contributor.author Cyr, Derek
dc.contributor.author Fowler, Vance Garrison Jr
dc.contributor.author Maskarinec, Stacey A
dc.contributor.author Ruffin, Felicia
dc.contributor.author Souli, Maria
dc.contributor.author Thaden, Joshua
dc.date.accessioned 2018-07-16T17:27:34Z
dc.date.available 2018-07-16T17:27:34Z
dc.date.issued 2017-01
dc.identifier ofx132
dc.identifier.issn 2328-8957
dc.identifier.issn 2328-8957
dc.identifier.uri https://hdl.handle.net/10161/17241
dc.description.abstract The species-specific risk of cardiac device-related infection (CDRI) among bacteremic patients is incompletely understood.We conducted a prospective cohort study of hospitalized patients from October 2002 to December 2014 with a cardiac device (CD) and either Staphylococcus aureus bacteremia (SAB) or Gram-negative bacteremia (GNB). Cardiac devices were defined as either prosthetic heart valves (PHVs), including valvular support rings, permanent pacemakers (PPMs)/automatic implantable cardioverter defibrillators (AICDs), or left ventricular assist devices (LVADs).During the study period, a total of 284 patients with ≥1 CD developed either SAB (n = 152 patients) or GNB (n = 132 patients). Among the 284 patients, 150 (52.8%) had PPMs/AICDs, 72 (25.4%) had PHVs, 4 (1.4%) had LVADs, and 58 (20.4%) had >1 device present. Overall, 54.6% of patients with SAB and 16.7% of patients with GNB met criteria for definite CDRI (P < .0001). Multivariable logistic regression analysis revealed that 3 bacterial species were associated with an increased risk for CDRI: Staphylococcus aureus (odds ratio [OR] = 5.57; 95% confidence interval [CI], 2.16-14.36), Pseudomonas aeruginosa (OR = 50.28; 95% CI, 4.16-606.93), and Serratia marcescens (OR = 7.75; 95% CI, 1.48-40.48).Risk of CDRI among patients with bacteremia varies by species. Cardiac device-related infection risk is highest in patients with bacteremia due to S aureus, P aeruginosa, or S marcescens. By contrast, it is lower in patients with bacteremia due to other species of Gram-negative bacilli. Patients with a CD who develop bacteremia due to either P aeruginosa or S marcescens should be considered for diagnostic imaging to evaluate for the presence of CDRI.
dc.language eng
dc.publisher OXFORD UNIV PRESS INC
dc.relation.ispartof Open forum infectious diseases
dc.relation.isversionof 10.1093/ofid/ofx132
dc.subject Gram-negative bacteremia
dc.subject S aureus bacteremia
dc.subject cardiac device-related infection
dc.subject pacemaker infection
dc.subject prosthetic valve endocarditis
dc.title The Risk of Cardiac Device-Related Infection in Bacteremic Patients Is Species Specific: Results of a 12-Year Prospective Cohort.
dc.type Journal article
dc.date.updated 2018-07-16T17:27:32Z
pubs.begin-page ofx132
pubs.issue 3
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Duke Clinical Research Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Molecular Genetics and Microbiology
pubs.organisational-group Basic Science Departments
pubs.organisational-group Medicine, Infectious Diseases
pubs.organisational-group Medicine
pubs.organisational-group Clinical Science Departments
pubs.publication-status Published
pubs.volume 4


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