Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults.
Abstract
To determine whether combinations of inflammatory markers are related to physical
function.secondary analysis of baseline of three observational studies of community-dwelling
older adults MEASUREMENTS: The baseline data from 3 cohorts of older adults with different
health and disease status were employed. Twenty markers of inflammation and metabolism
were individually assessed for correlation with usual gait speed and were separated
into robust and impairment quartiles. For the robustness and impairment indices, individual
markers were selected using step-wise regression over bootstrapping iterations, and
regression coefficients were estimated for the markers individually and collectively
as an additive score.We developed a robustness index involving 6 markers and an impairment
index involving 8 markers corresponding positively and negatively with gait speed.
Two markers, glycine and tumor necrosis factor receptor 1 (TNFR1), appeared only in
the robustness index, and TNFR2; regulated on activation, normal T-cell expressed
and secreted; the amino acid factor; and matrix metallopeptidase 3; appeared only
in the impairment index.Indices of biomarkers were associated with robust and impaired
physical performance but differ, in composition suggesting potential biological differences
that may contribute to robustness and impairment.
Type
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https://hdl.handle.net/10161/17282Published Version (Please cite this version)
10.1111/jgs.15393Publication Info
Zuo, Xintong; Luciano, Alison; Pieper, Carl F; Bain, James R; Kraus, Virginia B; Kraus,
William E; ... Cohen, Harvey J (2018). Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical
Function in Older Adults. Journal of the American Geriatrics Society. 10.1111/jgs.15393. Retrieved from https://hdl.handle.net/10161/17282.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
James R. Bain
Professor in Medicine
Harvey Jay Cohen
Walter Kempner Distinguished Professor of Medicine, in the School of Medicine
Dr. Cohen's research program includes clinical research relating to aspects of the
pathways to functional decline and reilience with aging, geriatric assessment, and
cancer and anemia in the elderly. Pathways to functional decline are being explored
through the NIA funded Claude Pepper Older Americans Independence Center, and includes
studies of the contributions of age related physiologic change, in particular changes
in inflammatory parameters, comorbid diseases and con
Virginia Byers Kraus
Mary Bernheim Distinguished Professor of Medicine
My special area of expertise is as a clinician scientist investigating osteoarthritis.
Osteoarthritis is the most common form of joint disease in man and its incidence increases
with age. It is a problem of increasing concern to the medical community due to the
increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist,
I endeavor to study this disease from bedside to bench. The work in this laboratory
focuses on osteoarthritis and deals with the m
William Erle Kraus
Richard and Pat Johnson University Distinguished Professor
My training, expertise and research interests range from human integrative physiology
and genetics to animal exercise models to cell culture models of skeletal muscle adaptation
to mechanical stretch. I am trained clinically as an internist and preventive cardiologist,
with particular expertise in preventive cardiology and cardiac rehabilitation. My
research training spans molecular biology and cell culture, molecular genetics, and
integrative human exercise physiology and metabolism. I pr
Miriam C. Morey
Professor Emeritus of Medicine
The general focus of Dr. Morey's work is exercise and aging. All of her research examines
how physical activity, exercise training, or physical fitness influence the physical
functioning and/or pyschosocial quality of life of older adults. She directs a supervised
hospital-based program for older adults, which is used to examine longitudinally the
effects of exercise training on the musculoskeletal, articular, and cardiorespiratory
systems. Furthermore, she has a number of studies that examine h
Carl F. Pieper
Professor of Biostatistics & Bioinformatics
Analytic Interests. 1) Issues in the Design of Medical Experiments: I explore the
use of reliability/generalizability models in experimental design. In addition to
incorporation of reliability, I study powering longitudinal trials with multiple outcomes
and substantial missing data using Mixed models. 2) Issues in the Analysis of Repeated
Measures Designs & Longitudinal Data: Use of Hierarchical Linear Models (HLM) or Mixed
Models in modeling trajectories of multipl
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