Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood.
Abstract
Aging is characterized by deleterious immune and metabolic changes, but the onset
of these changes is unknown. We measured immune and metabolic biomarkers in adults
beginning at age 30. To our knowledge, this is the first study to evaluate these biomarkers
in adults aged 30 to over 80. Biomarkers were quantified in 961 adults. Tumor necrosis
factor alpha (TNF-α), tumor necrosis factor receptor I (TNFR-I), tumor necrosis factor
receptor II (TNFR-II), interleukin (IL)-2, IL-6, VCAM-I, D-Dimer, G-CSF, regulated
on activation, normal T cell expressed and secreted (RANTES), matrix metalloproteinase-3
(MMP-3), adiponectin, and paraoxonase activity were measured by ELISA. Acylcarnitines
and amino acids (AAs) were measured by mass spectrometry and reduced to a single factor
using principal components analysis (PCA). Glycine was analyzed separately. The relationship
between age and biomarkers was analyzed by linear regression with sex, race, and body
mass index (BMI) as covariates. Age was positively correlated with TNF-α, TNFR-I,
TNFR-II, IL-6, IL-2, VCAM-1, D-Dimer, MMP-3, adiponectin, acylcarnitines, and AAs.
Age was negative correlated with G-CSF, RANTES, and paraoxonase activity. BMI was
significant for all biomarkers except IL-2, VCAM-1, RANTES, paraoxonase activity,
and the AA factor. Excluding MMP-3, greater BMI was associated with potentially adverse
changes in biomarker concentrations. Age-related changes in immune and metabolic biomarkers,
known to be associated with poor outcomes in older adults, begin as early as the thirties.
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https://hdl.handle.net/10161/17283Published Version (Please cite this version)
10.1093/gerona/gly121Collections
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James R. Bain
Professor in Medicine
Harvey Jay Cohen
Professor of Medicine
Dr. Cohen's research program includes clinical research relating to aspects of the
pathways to functional decline and reilience with aging, geriatric assessment, and
cancer and anemia in the elderly. Pathways to functional decline are being explored
through the NIA funded Claude Pepper Older Americans Independence Center, and includes
studies of the contributions of age related physiologic change, in particular changes
in inflammatory parameters, comorbid diseases and con
Olga Ilkayeva
Assistant Professor in Medicine
Olga Ilkayeva, Ph.D., is the Director of the Metabolomics Core Laboratory at Duke
Molecular Physiology Institute. She received her Ph.D. training in Cell Regulation
from UT Southwestern Medical Center at Dallas, TX. Her postdoctoral research in the
laboratory of Dr. Chris Newgard at Duke University Medical Center focused on lipid
metabolism and regulation of insulin secretion. As a research scientist at the Stedman
Nutrition and Metabolism Center, Dr. Ilkayeva expanded her studies to include the
Virginia Byers Kraus
Professor of Medicine
My special area of expertise is as a clinician scientist investigating osteoarthritis.
Osteoarthritis is the most common form of joint disease in man and its incidence increases
with age. It is a problem of increasing concern to the medical community due to the
increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist,
I endeavor to study this disease from bedside to bench. The work in this laboratory
focuses on osteoarthritis and deals w
William Erle Kraus
Richard and Pat Johnson University Distinguished Professor
My training, expertise and research interests range from human integrative physiology
and genetics to animal exercise models to cell culture models of skeletal muscle adaptation
to mechanical stretch. I am trained clinically as an internist and preventive cardiologist,
with particular expertise in preventive cardiology and cardiac rehabilitation. My
research training spans molecular biology and cell culture, molecular genetics, and
integrative human exercise physiology and metabolism. I pr
Miriam C. Morey
Professor in Medicine
The general focus of Dr. Morey's work is exercise and aging. All of her research
examines how physical activity, exercise training, or physical fitness influence the
physical functioning and/or pyschosocial quality of life of older adults. She directs
a supervised hospital-based program for older adults, which is used to examine longitudinally
the effects of exercise training on the musculoskeletal, articular, and cardiorespiratory
systems. Furthermore, she has a number of studies that e
Laura Kristin Newby
Professor of Medicine
Research Description General Focus: Clinical investigation the process and treatment
of acute and chronic coronary artery disease and systems issues for delivery of care
to patients with these illnesses. Particular interests include management of patients
with chest pain and unstable angina, evaluation of the use of biochemical markers
other than CK-MB for diagnosis and risk stratification in these patients, issues related
to coronary artery disease in women, and systems issues
Daniel Christopher Parker
Assistant Professor of Medicine
Biological aging is the greatest risk factor for most chronic diseases, including
frailty and dementia. The geroscience hypothesis posits that interventions that target
aspects of biological aging may delay or prevent many of these diseases simultaneously.
My research centers on understanding the mechanisms of interventions that affect biological
aging, like exercise training and caloric restriction and using that understanding
to develop therapies that maintain cognitive and physical function i
Carl F. Pieper
Professor of Biostatistics & Bioinformatics
Analytic Interests. 1) Issues in the Design of Medical Experiments: I explore the
use of reliability/generalizability models in experimental design. In addition to
incorporation of reliability, I study powering longitudinal trials with multiple outcomes
and substantial missing data using Mixed models. 2) Issues in the Analysis of Repeated
Measures Designs & Longitudinal Data: Use of Hierarchical Linear Models (HLM) or Mixed
Models in modeling trajectories of multipl
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