Relationship between sleep and exercise as colorectal cancer survivors transition off treatment.
Abstract
The primary objective of this study was to evaluate the relationship between exercise
and sleep disturbance in a sample of individuals diagnosed with stage I, II, and III
colorectal cancer (CRC) as patients transitioned off first-line treatment. We also
sought to identify heterogeneity in the relationship between sleep disturbance and
exercise.Data were obtained from the MY-Health study, a community-based observational
study of adults diagnosed with cancer. Patient-Reported Outcomes Measurement Information
System® (PROMIS) measures (e.g., PROMIS Sleep) were administered, and participants
self-reported demographics, comorbidities, cancer treatment, and exercise. Regression
mixture and multiple regression models were used to evaluate the relationship between
sleep disturbance and exercise cross-sectionally at an average of 10 months after
diagnosis, and the change in sleep disturbance over a 7-month period, from approximately
10 to 17 months post-diagnosis.Patients whose exercise was categorized as likely at
or above American College of Sports Medicine's guidelines did not report statistically
better sleep quality compared to patients who were classified as not active. However,
retirement (B = - 2.4), anxiety (B = 0.21), and fatigue (B = 0.24) had statistically
significant relationships with sleep disturbance (p < 0.05). Increase in exercise
was not significantly associated with a decrease in sleep disturbance. No statistical
heterogeneity was revealed in the relationship between sleep and exercise.Further
prospective research using an objective measure of exercise is warranted to confirm
or refute the nature of the relationship between exercise and sleep disturbance in
individuals diagnosed with CRC transitioning off first-line treatment.
Type
Journal articlePermalink
https://hdl.handle.net/10161/17317Published Version (Please cite this version)
10.1007/s00520-018-4110-8Publication Info
Coles, Theresa; Bennett, Antonia V; Tan, Xianming; Battaglini, Claudio L; Sanoff,
Hanna K; Basch, Ethan; ... Reeve, Bryce B (2018). Relationship between sleep and exercise as colorectal cancer survivors transition
off treatment. Supportive care in cancer : official journal of the Multinational Association of Supportive
Care in Cancer, 26(8). pp. 2663-2673. 10.1007/s00520-018-4110-8. Retrieved from https://hdl.handle.net/10161/17317.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Theresa Marie Coles
Assistant Professor in Population Health Sciences
Theresa Coles, Ph.D., is a health outcomes methodologist with a focus on measuring
and evaluating patient-reported outcomes (PROs) and other clinical outcomes assessments
(COAs), integrating PRO measures in clinical care, and improving interpretation of
patient-centered outcome scores for use in healthcare delivery and clinical research
settings to inform decision making.
My research program is comprised of 3 pillars:
Enhance the assessment of physical funct
Bryce B. Reeve
Professor in Population Health Sciences
Dr. Bryce Reeve is a Professor of Population Health Sciences and Professor of Pediatrics
at Duke University School of Medicine. He also serves as Director of the Center for
Health Measurement since 2017. Trained in psychometric methods, Dr. Reeve’s work
focuses on assessing the impact of disease and treatments on the lives of patients
and their caregivers. This includes the development of clinical outcome assessments
using both qualitative and quantitative methods, and
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