Perspectives on genetic and genomic technologies in an academic medical center: the duke experience.
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In this age of personalized medicine, genetic and genomic testing is expected to become instrumental in health care delivery, but little is known about its actual implementation in clinical practice.We surveyed Duke faculty and healthcare providers to examine the extent of genetic and genomic testing adoption. We assessed providers' use of genetic and genomic testing options and indications in clinical practice, providers' awareness of pharmacogenetic applications, and providers' opinions on returning research-generated genetic test results to participants. Most clinician respondents currently use family history routinely in their clinical practice, but only 18 percent of clinicians use pharmacogenetics. Only two respondents correctly identified the number of drug package inserts with pharmacogenetic indications. We also found strong support for the return of genetic research results to participants. Our results demonstrate that while Duke healthcare providers are enthusiastic about genomic technologies, use of genomic tools outside of research has been limited. Respondents favor return of research-based genetic results to participants, but clinicians lack knowledge about pharmacogenetic applications. We identified challenges faced by this institution when implementing genetic and genomic testing into patient care that should inform a policy and education agenda to improve provider support and clinician-researcher partnerships.
Published Version (Please cite this version)10.3390/jpm5020067
Publication InfoSimmons, Leigh; Ginsburg, Geoffrey; Katsanis, Sara; Minear, Mollie; Vorderstrasse, Allison; Rakhra-Burris, Tejinder; ... Reeves, Jason W (2015). Perspectives on genetic and genomic technologies in an academic medical center: the duke experience. Journal of personalized medicine, 5(2). pp. 67-82. 10.3390/jpm5020067. Retrieved from https://hdl.handle.net/10161/17567.
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Professor of Medicine
Dr. Geoffrey S. Ginsburg's research interests are in the development of novel paradigms for developing and translating genomic information into medical practice and the integration of personalized medicine into health care.
Instructor in the Duke Initiative for Science & Society
Sara Huston Katsanis is faculty instructor in the Initiative for Science & Society at Duke University. Her policy research focuses on genetic testing applications in humanitarian efforts, medicine and law enforcement. She researches ethical and policy challenges in the applications of genomics to human identification in contexts, such as human trafficking, migration, and adoption fraud. Past research explored direct-­to-­consumer genetic testing, pharmacogeneti
Consulting Professor in the School of Nursing
Dr. Leigh Ann Simmons is Associate Professor and Chair of the Faculty Governance Association in the Duke University School of Nursing, Faculty Director for All Babies and Children Thrive (ABC Thrive), and Chair of the Faculty Advisory Council for Bass Connections. The overall aim of her research is to promote population health equity by reducing disparities in chronic disease risk among vulnerable and medically underserved populations. Her research has been funded by the USDA, the NIH, the Ve
Dorothy L. Powell Term Chair of Nursing
Dr. Vorderstrasse is an Adult Nurse Practitioner whose clinical practice and scholarship focuses on chronic illness, particularly in ethnic minority populations. Dr. Vorderstrasse's doctoral dissertation research, recent publications, and national presentations illuminate the relationships of psychosocial factors with dietary intake in Black American women with Type 2 diabetes. She is a core team member of Durham Health Innovations: Partnership IMPACTS Diabetes. Dr. Vorderstrasse has also examin
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