Perspectives on genetic and genomic technologies in an academic medical center: the duke experience.

Abstract

In this age of personalized medicine, genetic and genomic testing is expected to become instrumental in health care delivery, but little is known about its actual implementation in clinical practice.We surveyed Duke faculty and healthcare providers to examine the extent of genetic and genomic testing adoption. We assessed providers' use of genetic and genomic testing options and indications in clinical practice, providers' awareness of pharmacogenetic applications, and providers' opinions on returning research-generated genetic test results to participants. Most clinician respondents currently use family history routinely in their clinical practice, but only 18 percent of clinicians use pharmacogenetics. Only two respondents correctly identified the number of drug package inserts with pharmacogenetic indications. We also found strong support for the return of genetic research results to participants. Our results demonstrate that while Duke healthcare providers are enthusiastic about genomic technologies, use of genomic tools outside of research has been limited. Respondents favor return of research-based genetic results to participants, but clinicians lack knowledge about pharmacogenetic applications. We identified challenges faced by this institution when implementing genetic and genomic testing into patient care that should inform a policy and education agenda to improve provider support and clinician-researcher partnerships.

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Published Version (Please cite this version)

10.3390/jpm5020067

Publication Info

Katsanis, Sara Huston, Mollie A Minear, Allison Vorderstrasse, Nancy Yang, Jason W Reeves, Tejinder Rakhra-Burris, Robert Cook-Deegan, Geoffrey S Ginsburg, et al. (2015). Perspectives on genetic and genomic technologies in an academic medical center: the duke experience. Journal of personalized medicine, 5(2). pp. 67–82. 10.3390/jpm5020067 Retrieved from https://hdl.handle.net/10161/17567.

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Scholars@Duke

Sara Huston Katsanis

Instructor in the Duke Initiative for Science & Society

Sara Huston Katsanis is faculty instructor in the Initiative for Science & Society at Duke University. Her policy research focuses on genetic testing applications in humanitarian efforts, medicine and law enforcement. She researches ethical and policy challenges in the applications of genomics to human identification in contexts, such as human trafficking, migration, and adoption fraud. Past research explored direct-­to-­consumer genetic testing, pharmacogenetics drug labeling, familial searching of CODIS, and surreptitious collection of DNA. Katsanis received a MS in Medical Genetics in 1997, then worked as a DNA Analyst at the Harris County Medical Examiner’s Office, and then managed the Johns Hopkins DNA Diagnostic Laboratory. By 2006, Katsanis began genetics policy research working with the Genetics & Public Policy Center in Washington, DC. She joined Duke in 2009.

Yang

Nancy Yang

House Staff

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