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Characterization of the standard and recommended CODIS markers.

dc.contributor.author Katsanis, Sara
dc.contributor.author Wagner, Jennifer K
dc.date.accessioned 2018-10-05T15:44:13Z
dc.date.available 2018-10-05T15:44:13Z
dc.date.issued 2013-01
dc.identifier.issn 0022-1198
dc.identifier.issn 1556-4029
dc.identifier.uri https://hdl.handle.net/10161/17572
dc.description.abstract As U.S. courts grapple with constitutional challenges to DNA identification applications, judges are resting legal decisions on the fingerprint analogy, questioning whether the information from a DNA profile could, in light of scientific advances, reveal biomedically relevant information. While CODIS loci were selected largely because they lack phenotypic associations, how this criterion was assessed is unclear. To clarify their phenotypic relevance, we describe the standard and recommended CODIS markers within the context of what is known currently about the genome. We characterize the genomic regions and phenotypic associations of the 24 standard and suggested CODIS markers. None of the markers are within exons, although 12 are intragenic. No CODIS genotypes are associated with known phenotypes. This study provides clarification of the genomic significance of the key identification markers and supports--independent of the forensic scientific community--that the CODIS profiles provide identification but not sensitive or biomedically relevant information.
dc.language eng
dc.relation.ispartof Journal of forensic sciences
dc.relation.isversionof 10.1111/j.1556-4029.2012.02253.x
dc.subject Humans
dc.subject Genetic Markers
dc.subject DNA Fingerprinting
dc.subject Microsatellite Repeats
dc.subject Genotype
dc.subject Phenotype
dc.subject Mutation
dc.subject Polymorphism, Single Nucleotide
dc.subject Introns
dc.subject Databases, Genetic
dc.subject Forensic Genetics
dc.subject Genetic Loci
dc.title Characterization of the standard and recommended CODIS markers.
dc.type Journal article
dc.date.updated 2018-10-05T15:44:13Z
pubs.begin-page S169
pubs.end-page S172
pubs.issue SUPPL. 1
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group Duke
pubs.organisational-group Duke Science & Society
pubs.organisational-group Initiatives
pubs.publication-status Published
pubs.volume 58 Suppl 1


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