Tissue-Resident Macrophages in Fungal Infections.
Abstract
Invasive fungal infections result in high morbidity and mortality. Host organs targeted
by fungal pathogens vary depending on the route of infection and fungal species encountered.
Cryptococcus neoformans infects the respiratory tract and disseminates throughout
the central nervous system. Candida albicans infects mucosal tissues and the skin,
and systemic Candida infection in rodents has a tropism to the kidney. Aspergillus
fumigatus reaches distal areas of the lung once inhaled by the host. Across different
tissues in naïve hosts, tissue-resident macrophages (TRMs) are one of the most populous
cells of the innate immune system. Although they function to maintain homeostasis
in a tissue-specific manner during steady state, TRMs may function as the first line
of defense against invading pathogens and may regulate host immune responses. Thus,
in any organs, TRMs are uniquely positioned and specifically programmed to function.
This article reviews the current understanding of the roles of TRMs during major fungal
infections.
Type
Journal articleSubject
AspergillusCandida
Cryptococcus
alveolar macrophages
fungal infections
microglia
tissue-resident macrophages
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https://hdl.handle.net/10161/17647Published Version (Please cite this version)
10.3389/fimmu.2017.01798Publication Info
Xu, Shengjie; & Shinohara, Mari L (2017). Tissue-Resident Macrophages in Fungal Infections. Frontiers in immunology, 8(DEC). pp. 1798. 10.3389/fimmu.2017.01798. Retrieved from https://hdl.handle.net/10161/17647.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Mari L. Shinohara
Professor of Integrative Immunobiology
Shinohara Lab WebsiteImmune responses against pathogens are essential for host protection,
but excessive and uncontrolled immune reactions can lead to autoimmunity. How does
our immune system keep the balance fine-tuned? This is a central question being asked
in my laboratory.
The immune system needs to detect pathogens quickly and effectively. This is performed
by the innate immune system, which includes cells such as mac
Shengjie Xu
Research Assistant, Ph D Student
Program Start Year: 2013Mari Shinohara Laboratory"Novel Heterogeneous Alveolar Macrophage
Subpopulations during Early Fungal Infection"
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